{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:14:36Z","timestamp":1792059276765,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T00:00:00Z","timestamp":1292457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase1 alpha subunit 3 (ATP1\u03b1<jats:sub>3<\/jats:sub>) is one of many essential components that maintain the sodium and potassium gradients across the plasma membrane in animal cells. Mutations in the <jats:italic>ATP1A3<\/jats:italic> gene cause rapid\u2010onset of dystonia parkinsonism (RDP), a rare movement disorder characterized by sudden onset of dystonic spasms and slowness of movement. To achieve a better understanding of the pathophysiology of the disease, we used immunohistochemical approaches to describe the regional and cellular distribution of ATP1\u03b1<jats:sub>3<\/jats:sub> in the adult mouse brain. Our results show that localization of ATP1\u03b1<jats:sub>3<\/jats:sub> is restricted to neurons, and it is expressed mostly in projections (fibers and punctuates), but cell body expression is also observed. We found high expression of ATP1\u03b1<jats:sub>3<\/jats:sub> in GABAergic neurons in all nuclei of the basal ganglia (striatum, globus pallidus, subthalamic nucleus, and substantia nigra), which is a key circuitry in the fine movement control. Several thalamic nuclei structures harboring connections to and from the cortex expressed high levels of the ATP1\u03b1<jats:sub>3<\/jats:sub> isoform. Other structures with high expression of ATP1\u03b1<jats:sub>3<\/jats:sub> included cerebellum, red nucleus, and several areas of the pons (reticulotegmental nucleus of pons). We also found high expression of ATP1\u03b1<jats:sub>3<\/jats:sub> in projections and cell bodies in hippocampus; most of these ATP1\u03b1<jats:sub>3<\/jats:sub>\u2010positive cell bodies showed colocalization to GABAergic neurons. ATP1\u03b1<jats:sub>3<\/jats:sub> expression was not significant in the dopaminergic cells of substantia nigra. In conclusion, and based on our data, ATP1\u03b1<jats:sub>3<\/jats:sub> is widely expressed in neuronal populations but mainly in GABAergic neurons in areas and nuclei related to movement control, in agreement with RDP symptoms. J. Comp. Neurol. 519:376\u2010404, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22524","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T15:04:23Z","timestamp":1287759863000},"page":"376-404","source":"Crossref","is-referenced-by-count":157,"title":["Distribution of Na\/K\u2010ATPase alpha 3 isoform, a sodium\u2010potassium P\u2010type pump associated with rapid\u2010onset of dystonia parkinsonism (RDP) in the adult mouse 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