{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:16:39Z","timestamp":1790900199769,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T00:00:00Z","timestamp":1293580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal neovascularization, such as that occurring in proliferative diabetic retinopathy and retinopathy of prematurity, can have serious effects on visual function. By using a mouse model of neovascularization, oxygen\u2010induced retinopathy (OIR), the interplay among angiogenesis, neuronal function, and the macro\u2010 and micro\u2010glial response was explored. OIR was induced by exposure of mice to 75% oxygen from postnatal day 7 (P7) to P11 and then room air until P18. Controls were reared in room air. Blood vessel development was assessed by using fluorescence histochemistry. Aberrant intravitreal neovascularization was present across all eccentricities of retina in mice with OIR, whereas the number of vessels present in the deep plexus was reduced in the central regions. Neuronal function of both the rod and cone pathways, assessed by using the electroretinogram, was found to be significantly reduced in OIR. This may in part be explained by an alteration in photoreceptor outer segment morphology and also a loss of neurons and their synapses in the inner nuclear and plexiform layers of the central retina. In addition, there was an increase in the number of gliotic M\u00fcller cells and microglia in mice with OIR and the increase in the number of these cells correlated with the absence of the deep plexus. This indicates that the activity of both macro\u2010 and microglia is altered in regions where the deep plexus blood supply is deficient. Treatments or genetic manipulations directed toward amelioration of proliferative retinopathy need to address not only the vascular changes but also the alterations in neuronal and macro\u2010 and microglial function. J. Comp. Neurol. 519:506\u2013527, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22530","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T14:29:17Z","timestamp":1287498557000},"page":"506-527","source":"Crossref","is-referenced-by-count":96,"title":["Characterization of retinal function and glial cell response in a mouse model of oxygen\u2010induced retinopathy"],"prefix":"10.1002","volume":"519","author":[{"given":"K.A.","family":"Vessey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Wilkinson\u2010Berka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"37","article-title":"Quantitative histology of Wallerian degeneration: I. Nuclear population in rabbit sciatic nerve","volume":"80","author":"Abercrombie M","year":"1946","journal-title":"J Anat"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.506"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1337"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2008.10.014"},{"key":"e_1_2_7_7_1","first-page":"2128","article-title":"Vascular changes and their mechanisms in the feline model of retinopathy of prematurity","volume":"33","author":"Chan\u2010Ling T","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_8_1","first-page":"1201","article-title":"The effect of oxygen on vasoformative cell division. Evidence that \u2018physiological hypoxia\u2019 is the stimulus for normal retinal vasculogenesis","volume":"36","author":"Chan\u2010Ling T","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1522"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026032005521"},{"key":"e_1_2_7_12_1","first-page":"2481","article-title":"Evidence for a brief period of enhanced oxygen susceptibility in the rat model of oxygen\u2010induced retinopathy","volume":"43","author":"Dembinska O","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20900"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21449"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20680"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.05.020"},{"key":"e_1_2_7_17_1","first-page":"1321","article-title":"Muller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina","volume":"25","author":"Eisenfeld AJ","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_18_1","first-page":"31","article-title":"Development of the cone photoreceptor mosaic in the mouse retina revealed by fluorescent cones in transgenic mice","volume":"9","author":"Fei Y","year":"2003","journal-title":"Mol Vis"},{"key":"e_1_2_7_19_1","first-page":"1588","article-title":"The development of scotopic sensitivity","volume":"41","author":"Fulton AB","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(78)90119-0"},{"key":"e_1_2_7_21_1","first-page":"168","article-title":"Rod photoreceptors in infant rats with a history of oxygen exposure","volume":"40","author":"Fulton AB","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.4.499"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1226"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.06.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523809090038"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970915)386:1<2::AID-CNE2>3.0.CO;2-6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902490406"},{"key":"e_1_2_7_28_1","first-page":"2070","article-title":"The A\u2010wave of the human electroretinogram and rod receptor function","volume":"31","author":"Hood DC","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.10.021"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.02.026"},{"key":"e_1_2_7_31_1","first-page":"1","article-title":"Microglia\u2010specific localisation of a novel calcium binding protein, Iba1","volume":"57","author":"Ito D","year":"1998","journal-title":"Brain Res"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.09.003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0016"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01221"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8077-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-02-00563.1996"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp008003"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0842"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450105"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132528"},{"key":"e_1_2_7_41_1","first-page":"2071","article-title":"Effect of prior oxygen exposure on the electroretinographic responses of infant rats","volume":"36","author":"Reynaud X","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29683"},{"key":"e_1_2_7_43_1","first-page":"101","article-title":"Oxygen\u2010induced retinopathy in the mouse","volume":"35","author":"Smith LE","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150754011"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689109013875"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.07.001"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1474"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20525"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00006-8"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1639-5"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.035"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.09.003"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0392"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20000"},{"key":"e_1_2_7_56_1","first-page":"1653","article-title":"Role of astrocytes in the control of developing retinal vessels","volume":"38","author":"Zhang Y","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.12.013"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.22530","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.22530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:08:21Z","timestamp":1697051301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.22530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,29]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2,15]]}},"alternative-id":["10.1002\/cne.22530"],"URL":"https:\/\/doi.org\/10.1002\/cne.22530","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,29]]}}}