{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:32:28Z","timestamp":1774611148305,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T00:00:00Z","timestamp":1306108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The murine olfactory system consists of main and accessory systems that perform distinct and overlapping functions. The main olfactory epithelium (MOE) is primarily involved in the detection of volatile odorants, while neurons in the vomeronasal organ (VNO), part of the accessory olfactory system, are important for pheromone detection. During development, the MOE and VNO both originate from the olfactory pit; however, the mechanisms regulating development of these anatomically distinct organs from a common olfactory primordium are unknown. Here we report that two closely related zinc\u2010finger transcription factors, FEZF1 and FEZF2, regulate the identity of MOE sensory neurons and are essential for the survival of VNO neurons respectively. <jats:italic>Fezf1<\/jats:italic> is predominantly expressed in the MOE while <jats:italic>Fezf2<\/jats:italic> expression is restricted to the VNO. In <jats:italic>Fezf1<\/jats:italic>\u2010deficient mice, olfactory neurons fail to mature and also express markers of functional VNO neurons. In <jats:italic>Fezf2<\/jats:italic>\u2010deficient mice, VNO neurons degenerate prior to birth. These results identify <jats:italic>Fezf1<\/jats:italic> and <jats:italic>Fezf2<\/jats:italic> as important regulators of olfactory system development and sensory neuron identity. J. Comp. Neurol. 519:1829\u20131846, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22596","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T18:33:19Z","timestamp":1294857199000},"page":"1829-1846","source":"Crossref","is-referenced-by-count":36,"title":["<i>Fezf1<\/i> and <i>Fezf2<\/i> are required for olfactory development and sensory neuron identity"],"prefix":"10.1002","volume":"519","author":[{"given":"Matthew J.","family":"Eckler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William L.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Taghvaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan 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