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Layer 6 middle temporal area (MT)\u2010projecting neurons are particularly interesting, as they are the only deep\u2010layer cortical neurons that provide both corticocortical feedforward inputs (to area MT) and corticosubcortical feedback projections (to superior colliculus [SC]) (Fries et al. [1985] Exp Brain Res 58:613\u2013616). However, due to limitations in anatomical tracing techniques, little is known about the detailed morphologies of these cells. We therefore applied a genetically modified rabies virus as a retrograde tracer to fill the dendrites of projection neurons with green fluorescent protein (GFP) (Wickersham et al. [2007] Nat Methods 4:47\u201349). We injected virus into SC or area MT of macaque monkeys and examined labeled cells in V1. Two\u2010thirds of labeled neurons following SC injections were found in layer 5, consisting of \u201ctall\u2010tufted\u201d and \u201cnontufted\u201d cells; the remaining cells were layer 6 \u201cnontufted.\u201d Area MT injections labeled neurons in layers 4B and 6, as previously described (Shipp and Zeki [1989] Eur J Neurosci 1:309\u2013332). The layer 6 neurons projecting to MT were remarkably similar to the layer 6 SC\u2010projecting neurons. In contrast to the dense and focused dendritic arbors of layer 5 \u201ctall\u2010tufted\u201d pyramids, all \u201cnontufted\u201d cells had sparse, but unusually long basal dendrites. The nontufted cells closely resemble Meynert cells (le Gros Clark [1942] J Anat 76:369\u2013376; Winfield et al. [1983] Proc R Soc Lond B Biol Sci 217:129\u2013139), but the full in vivo reconstructions presented here show that their basal dendrites can extend much further (up to 1.2 mm) and are less asymmetric than inferred from Golgi reconstructions. J. Comp. Neurol., 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.22685","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T15:46:01Z","timestamp":1308066361000},"page":"52-80","source":"Crossref","is-referenced-by-count":33,"title":["Morphology of superior colliculus\u2010 and middle temporal area\u2010projecting neurons in primate primary visual cortex"],"prefix":"10.1002","volume":"520","author":[{"given":"Hoang L.","family":"Nhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Callaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"36","article-title":"Image procesing with ImageJ","volume":"11","author":"Abramoff MD","year":"2004","journal-title":"Biophotonics Int"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/3.5.412"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.139.3553.412"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-10-03600.2001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh154"},{"key":"e_1_2_6_7_1","first-page":"1","article-title":"Estudios sobre la corteza cerebral humana. 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