{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:04:42Z","timestamp":1782929082017,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The basic helix\u2010loop\u2010helix transcription factor NeuroD1 is expressed in embryonic and adult mouse olfactory epithelium (OE), as well as during epithelial regeneration, suggesting that it plays an important role in olfactory neurogenesis. We characterized NEUROD1\u2010expressing progenitors, determined their progeny in the adult OE, and identified a subtle phenotype in <jats:italic>\u0394NeuroD1<\/jats:italic>\u2010knockout mice. All olfactory sensory neurons (OSNs) derive from a <jats:italic>NeuroD1<\/jats:italic>\u2010expressing progenitor as shown by recombination\u2010mediated lineage tracing, as do other sensory receptors of the nose, including vomeronasal, nasal septal, and Grunenberg ganglion neurons. NEUROD1\u2010expressing cells are found among the globose basal cell population: they are actively proliferating and frequently coexpress Neurog1, but not the transit amplifying cell marker MASH1, nor the neuronal marker NCAM. As a consequence, NEUROD1\u2010expressing globose basal cells are best classified as immediate neuronal precursors. In adolescent <jats:italic>\u0394NeuroD1\u2010LacZ<\/jats:italic> knock\u2010in null mice the OE displays subtle abnormalities, as compared to wildtype and heterozygous littermates. In some areas of the OE, mature neurons are absent, or sparse, although those same areas retain immature OSNs and <jats:italic>LacZ<\/jats:italic>\u2010expressing progenitors, albeit both of these populations are smaller than expected. Our results support the conclusion that most, if not all, nasal chemosensory neurons derive from <jats:italic>NeuroD1<\/jats:italic>\u2010expressing globose basal cells of the immediate neuronal precursor variety. Moreover, elimination of <jats:italic>NeuroD1<\/jats:italic> by gene knockout, while it does not disrupt initial OSN differentiation, does compromise the integrity of parts of the olfactory epithelium by altering proliferation, neuronal differentiation, or neuronal survival there. J. Comp. Neurol. 519:3580\u20133596, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.22726","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T15:41:02Z","timestamp":1311867662000},"page":"3580-3596","source":"Crossref","is-referenced-by-count":56,"title":["Progenitor cell capacity of <i>NeuroD1<\/i>\u2010expressing globose basal cells in the mouse olfactory epithelium"],"prefix":"10.1002","volume":"519","author":[{"given":"Adam","family":"Packard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann","family":"Giel\u2010Moloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Leiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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