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These two cardinal features of retinal mosaics are disrupted, for certain cell types, in mice deficient for the Down syndrome cell adhesion molecule, Dscam, exhibiting an aberrant clustering of somata and fasciculation of dendrites. The <jats:italic>Dscam<\/jats:italic> mutant mouse retina also exhibits excess numbers of these same cell types. The present study compared these two features in <jats:italic>Dscam<\/jats:italic> mutant retinas with the <jats:italic>Bax<\/jats:italic> knockout retina, in which excess numbers of two of these cell types, the melanopsin\u2010positive retinal ganglion cells (MRGCs) and the dopaminergic amacrine cells (DACs), are also present. Whole retinas were immunolabeled for both populations, and every labeled soma was plotted. For the MRGCs, we found a gene dosage effect for <jats:italic>Dscam<\/jats:italic>, with the <jats:italic>Dscam<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> retinas showing smaller increases in cell number, clustering, and fasciculation. Curiously, <jats:italic>Bax<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> retinas, showing numbers of MRGCs intermediate to those found in the <jats:italic>Dscam<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and <jats:italic>Dscam<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> retinas, also had clustering and fasciculation phenotypes that were intermediate to retinas with those genotypes. DACs, by comparison, showed changes in both the <jats:italic>Dscam<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and the <jats:italic>Bax<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> retinas that did not correlate with their increases in DAC number. The fasciculation phenotype in the <jats:italic>Dscam<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> retina was particularly prominent despite only modest clustering. These results demonstrate that the somal clustering and fasciculation observed in the <jats:italic>Dscam<\/jats:italic> mutant retina are not unique to Dscam deficiency and are manifested distinctively by different retinal cell types. J. Comp. Neurol. 520:1349\u20131364, 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23033","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T14:08:19Z","timestamp":1323958099000},"page":"1349-1364","source":"Crossref","is-referenced-by-count":34,"title":["Neuronal clustering and fasciculation phenotype in Dscam\u2010 and Bax\u2010deficient mouse retinas"],"prefix":"10.1002","volume":"520","author":[{"given":"Patrick W.","family":"Keeley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buranee J.","family":"Sliff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy C.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Fuerst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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