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Cortex 17:2805\u20132819), we analyzed the impact of early BD on the retinal circuitry in adult, perceptually characterized cats (Burnat et al. [2005] Neuroreport 16:751\u2013754). In controls, large retinal ganglion cells exhibited a strong NFP signal in the soma and in the proximal parts of the dendritic arbors. The NFP\u2010immunoreactive dendrites typically branched into sublamina a of the inner plexiform layer (IPL), i.e., the OFF inner plexiform sublamina. In the retina of adult BD cats, however, most of the NFP\u2010immunoreactive ganglion cell dendrites branched throughout the entire IPL. The NFP\u2010immunoreactive cell bodies were less regularly distributed, often appeared in pairs, and had a significantly larger diameter compared with NFP\u2010expressing cells in control retinas. These remarkable differences in the immunoreactivity pattern were typically observed in temporal retina. In conclusion, we show that the anatomical organization typical of premature Y\u2010type retinal ganglion cells persists into adulthood even if normal visual experience follows for years upon an initial 6\u2010month period of BD. Binocular pattern deprivation possibly induces a lifelong OFF functional domination, normally apparent only during development, putting early high\u2010quality vision forward as a premise for proper ON\u2013OFF pathway segregation. These new observations for pattern\u2010deprived animals provide an anatomical basis for the well\u2010described motion perception deficits in congenital cataract patients. J. Comp. Neurol. 520:2414\u20132429, 2012. \u00a9 2012 Wiley Periodicals Inc.<\/jats:p>","DOI":"10.1002\/cne.23045","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T12:24:33Z","timestamp":1326284673000},"page":"2414-2429","source":"Crossref","is-referenced-by-count":20,"title":["Lack of early pattern stimulation prevents normal development of the alpha (Y) retinal ganglion cell population in the cat"],"prefix":"10.1002","volume":"520","author":[{"given":"Kalina","family":"Burnat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Van Der Gucht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wioletta 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