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Because the CT usually regenerates to reinnervate taste buds successfully within a few weeks, a persistence of taste disturbances may indicate alterations in central nervous function. Peripheral injury to other sensory nerves leads to glial responses at central terminals, which actively contribute to abnormal sensations arising from nerve damage. Therefore, the current study examined microglial and astrocytic responses in the first central gustatory relay, the nucleus of the solitary tract (nTS), after transection of the CT. Damage to the CT resulted in significant microglial responses in terms of morphological reactivity and an increased density of microglial cells from 2 to 20 days after injury. This increased microglial population resulted primarily from microglial proliferation from 1.5 to 3 days, which was supplemented by microglial migration within subdivisions of the nTS between days 2 and 3. Unlike other nerve injuries, CT injury did not result in recruitment of bone marrow\u2010derived precursors. Astrocytes also reacted in the nTS with increased levels of glial fibrillary acidic protein (GFAP) by 3 days, although none showed evidence of cell division. GFAP levels remained increased at 30 days, by which time microglial responses had resolved. These results show that nerve damage to the CT results in central glial responses, which may participate in long\u2010lasting taste alterations following CT lesion. J. Comp. Neurol. 520:2712\u20132729, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23069","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T07:20:57Z","timestamp":1328685657000},"page":"2712-2729","source":"Crossref","is-referenced-by-count":24,"title":["Glial responses after chorda tympani nerve injury"],"prefix":"10.1002","volume":"520","author":[{"given":"Dianna L.","family":"Bartel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.01.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1271\/bbb.70690","article-title":"Studies on taste: molecular biology and food science","volume":"72","author":"Abe K","year":"2008","journal-title":"Biosci Biotechnol 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