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It has been proposed that the transition from the free\u2010living <jats:italic>S. mansoni<\/jats:italic> miracidium to parasitic mother sporocyst depends on uptake of biogenic amines, e.g. serotonin, from the snail host. However, little is known about potential sources of serotonin in <jats:italic>B. glabrata<\/jats:italic> tissues. This investigation examined the localization of serotonin\u2010like immunoreactivity (5HTli) in the central nervous system (CNS) and peripheral tissues of <jats:italic>B. glabrata<\/jats:italic>. Emphasis was placed on the cephalic and anterior pedal regions that are commonly the sites of <jats:italic>S. mansoni<\/jats:italic> miracidium penetration. The anterior foot and body wall were densely innervated by 5HTli fibers but no peripheral immunoreactive neuronal somata were detected. Within the CNS, clusters of 5HTli neurons were observed in the cerebral, pedal, left parietal, and visceral ganglia, suggesting that the peripheral serotonergic fibers originate from the CNS. Double\u2010labeling experiments (biocytin backfill \u00d7 serotonin immunoreactivity) of the tentacular nerve and the three major pedal nerves (Pd n. 10, Pd n. 11, and Pd n. 12) disclosed central neurons that project to the cephalopedal periphery. Overall, the central distribution of 5HTli neurons suggests that, as in other gastropods, serotonin regulates the locomotion, reproductive, and feeding systems of <jats:italic>Biomphalaria<\/jats:italic>. The projections to the foot and body wall indicate that serotonin may also participate in defensive, nociceptive, or inflammation responses. These observations identify potential sources of host\u2010derived serotonin in this parasite\u2013host system. J. Comp. Neurol., 520:3236\u20133255, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23095","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T17:32:07Z","timestamp":1332437527000},"page":"3236-3255","source":"Crossref","is-referenced-by-count":22,"title":["Localization of serotonin in the nervous system of <i>Biomphalaria glabrata<\/i>, an intermediate host for schistosomiasis"],"prefix":"10.1002","volume":"520","author":[{"given":"Nadia","family":"Delgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067790"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1556\/ABiol.59.2008.Suppl.3","article-title":"Higher\u2010order control of the feeding network in Lymnaea","volume":"59","author":"Alania M","year":"2008","journal-title":"Acta Biol Hung"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(85)90148-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.01.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(81)90182-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1242\/jeb.65.2.361","article-title":"Properties of a symmetric pair of serotonin\u2010containing neurones in the cerebral ganglia of Planorbis","volume":"65","author":"Berry MS","year":"1976","journal-title":"J Exp Biol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90037-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1645\/0022-3395(2003)089[0429:ABOTSB]2.0.CO;2","article-title":"Altered behavior of the snail Biomphalaria glabrata as a result of infection with Schistosoma mansoni","volume":"89","author":"Boissier J","year":"2003","journal-title":"J Parasitol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/mollus\/66.1.83"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00091-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-432R"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2000.4500"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00359-003-0429-8","article-title":"Pharmacological and autoradiographical characterization of serotonin transporter\u2010like activity in sporocysts of the human blood fluke, Schistosoma mansoni","volume":"189","author":"Boyle JP","year":"2003","journal-title":"J Comp Physiol A Neuroethol Sens Neural Behav Physiol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.186870"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277659"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207457209147013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/3278462"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90145-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90114-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1955-9_4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902800109"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/07924259.1996.9672542"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1152\/jn.1997.78.6.2823","article-title":"Functional role of peptidergic anterior lobe neurones in male sexual behavior of the snail Lymnaea stagnalis","volume":"78","author":"de Boer PACM","year":"1997","journal-title":"J Neurophysiol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1017\/S0031182001008149","article-title":"Multiple strategies of schistosomes to meet their requirements in the intermediate snail host","volume":"123","author":"de Jong\u2010Brink M","year":"2001","journal-title":"Parasitology"},{"key":"e_1_2_7_26_1","unstructured":"DelgadoN VallejoDI MillerMW.2010.Localization of biogenic amines in the pond snailBiomphalaria glabrata. 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