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As a first step in investigating the role of kisspeptins in the European sea bass, a perciform fish, we studied the distribution of <jats:italic>kiss1<\/jats:italic> and <jats:italic>kiss2<\/jats:italic>\u2010expressing cells in the brain of males and females undergoing their first sexual maturation. Animals were examined at early and late in the reproductive season. We also examined the putative expression of estrogen receptors in kiss\u2010expressing cells and, finally, we investigated whether kisspeptins are expressed in the pituitary gland. We show that <jats:italic>kiss1<\/jats:italic>\u2010expressing cells were consistently detected in the habenula and, in mature males and females, in the rostral mediobasal hypothalamus. In both sexes, <jats:italic>kiss2<\/jats:italic>\u2010expressing cells were consistently detected at the level of the preoptic area, but the main <jats:italic>kiss2<\/jats:italic> mRNA\u2010positive population was observed in the dorsal hypothalamus, above and under the lateral recess. No obvious sexual differences in <jats:italic>kiss1<\/jats:italic> and <jats:italic>kiss2 mRNA<\/jats:italic> expression were detected. Additional studies based on confocal imaging clearly showed that most <jats:italic>kiss1<\/jats:italic> mRNA\u2010containing cells of the mediobasal hypothalamus strongly express <jats:italic>ER<\/jats:italic>\u03b1 and slightly express <jats:italic>ER<\/jats:italic>\u03b2<jats:italic>2<\/jats:italic>. At the pituitary level, both sexes exhibited kiss1 mRNA expression in most FSH\u03b2\u2010positive cells and never in LH\u03b2\u2010positive cells. J. Comp. Neurol. 521:933\u2013948, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23211","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T10:43:25Z","timestamp":1344422605000},"page":"933-948","source":"Crossref","is-referenced-by-count":78,"title":["Expression of kisspeptins in the brain and pituitary of the european sea bass (<i>Dicentrarchus labrax<\/i>)"],"prefix":"10.1002","volume":"521","author":[{"given":"Sebasti\u00e1n","family":"Escobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Felip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Madeleine","family":"Gueguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zanuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Kah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Servili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3690-09.2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312837"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2000.tb02131.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2003.12.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520902758311"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2010.07.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2004.07.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520297609116677"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119165109"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2008.03645.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.057"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4687(200103)247:3<217::AID-JMOR1013>3.0.CO;2-U"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4687(200103)247:3<229::AID-JMOR1014>3.0.CO;2-K"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.01.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5098"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_2007_050"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.52.Suppl_441"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb11442.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1282"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.04.026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.11.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.04.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.03.039"},{"key":"e_1_2_7_26_1","first-page":"797","article-title":"[1st immunocytochemical application of an anti\u2010dopamine antibody in the study of the central nervous system.]","volume":"295","author":"Geffard M","year":"1982","journal-title":"C R Seances Acad Sci III"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000101)429:1<144::AID-CNE11>3.0.CO;2-B"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10190"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.03.010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01558.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2004.05.009"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4765-11.2012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21339"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22408"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00213771"},{"key":"e_1_2_7_36_1","first-page":"705","article-title":"[Aminergic innervation of the hypothalamo\u2010hypophyseal system in Gambusia sp. 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