{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:30:41Z","timestamp":1790375441984,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lamina I of the spinal dorsal horn is a major site of integration and transmission to higher centers of nociceptive information from the periphery. One important primary afferent population that transmits such information to the spinal cord expresses substance P (SP). These fibers terminate in contact with lamina I projection neurons that express the SP receptor, also known as the neurokinin\u20101 receptor (NK\u20101r). Three types of lamina I projection neurons have been described: multipolar, fusiform, and pyramidal. Most neurons of the first two types are thought to be nociceptive and express the NK\u20101r, whereas most pyramidal neurons are nonnociceptive and do not express the NK\u20101r. In this immunocytochemical and behavioral study, we induced a neuropathic pain\u2010like condition in the rat by means of a polyethylene cuff placed around in the sciatic nerve. We document that this lesion led to a de novo expression of NK\u20101r on pyramidal neurons as well as a significant increase in SP\u2010immunoreactive innervation onto these neurons. These phenotypic changes were evident at the time of onset of neuropathic pain\u2010related behavior. Additionally, we show that, after a noxious stimulus (intradermal capsaicin injection), these NK\u20101r on pyramidal neurons were internalized, providing evidence that these neurons become responsive to peripheral noxious stimulation. We suggest that the changes following nerve lesion in the phenotype and innervation pattern of pyramidal neurons are of significance for neuropathic pain and\/or limb temperature regulation. J. Comp. Neurol. 521:1915\u20131928, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23267","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T14:20:02Z","timestamp":1353507602000},"page":"1915-1928","source":"Crossref","is-referenced-by-count":13,"title":["De novo expression of neurokinin\u20101 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion"],"prefix":"10.1002","volume":"521","author":[{"given":"Abeer 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