{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:50:34Z","timestamp":1789908634836,"version":"4.0.1"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal ganglion cells are categorized into multiple classes, including multiple types of bistratified ganglion cells (BGCs). The recent use of transgenic mouse lines with specific type(s) of ganglion cells that are labeled by fluorescent markers has facilitated the morphological and physiological studies of BGCs, particularly the directional\u2010selective BGCs. The most important benefit from using transgenic animals is the capability to perform in vivo gene manipulation. In particular, the Cre\/LoxP recombination system has become a powerful tool, allowing gene deletion, overexpression, and ectopic expression in a cell type\u2010specific and temporally controlled fashion. The key to this tool is the availability of Cre mouse lines with cell or tissue type\u2010specific expression of Cre recombinase. In this study we characterized the Cre\u2010positive retinal ganglion cells in a PCP2 (Purkinje cell protein 2)\u2010cre mouse line. We found that all of the Cre\u2010positive retinal ganglion cells were BGCs. Based on morphological criteria, we determined that they can be grouped into five types. The On\u2010 and Off\u2010dendrites of three of these types stratified outside of the cholinergic bands and differed from directional selective ganglion cells (DSGCs) morphologically. These cells were negative for Brn\u20103b and positive for both calretinin and CART retina markers. The remaining two types were identified as putative On\u2010Off and On\u2010DSGCs. This Cre mouse line could be useful for further studies of the molecular and functional properties of BGCs in mice. J. Comp. Neurol. 521:2165\u20132180, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23279","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T22:54:39Z","timestamp":1355266479000},"page":"2165-2180","source":"Crossref","is-referenced-by-count":22,"title":["Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2\u2010Cre transgenic mouse line"],"prefix":"10.1002","volume":"521","author":[{"given":"Elena","family":"Ivanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo\u2010Hua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1983.0014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91167-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902800108"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20304"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2010.08.039"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.139.3553.412"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007463"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00399-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902530204"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/1931034"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007094"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.02.079"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903560305"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903240303"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523808080929"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22387"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.037"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20970"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000814)424:1<1::AID-CNE1>3.0.CO;2-V"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.081"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095252389815215X"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22678"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.04.014"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970825)385:2<309::AID-CNE9>3.0.CO;2-5"},{"key":"e_1_2_7_26_1","first-page":"1680","article-title":"Evaluation of the adeno\u2010associated virus mediated long\u2010term expression of channelrhopsin\u20102 in the mouse retina","volume":"15","author":"Ivanova E","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.10.021"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22765"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0907-11.2011"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06739"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4779-09.2010"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20631"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.10.008"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008140"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.03.007"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008671"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.155.3764.841"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01646"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21746"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0564-11.2011"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03831.2002"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095252380001049X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/35069068"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20621"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22720"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.115857"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523802194107"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10323"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.06.020"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3165"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21912"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1497"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0033"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0032"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/292344a0"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90079-7"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-04762.1995"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001533"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004320"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.23279","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.23279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:38:56Z","timestamp":1696977536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.23279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,18]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,6,15]]}},"alternative-id":["10.1002\/cne.23279"],"URL":"https:\/\/doi.org\/10.1002\/cne.23279","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,18]]}}}