{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:17:51Z","timestamp":1696659471207},"reference-count":34,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Exogenous ciliary neurotrophic factor (CNTF) promotes motor neuron (MN) survival following trauma and in genetic models of MN disease. Unconditional disruption of the mouse CNTF receptor \u03b1 (CNTFR\u03b1) gene leads to MN loss, demonstrating a developmental role for endogenous CNTF receptor signaling. These data also suggest that CNTF receptors may promote adult MN survival and that appropriately manipulating the receptors could effectively treat adult MN disorders. This effort would greatly benefit from a better understanding of the roles played by CNTF receptors in adult MNs. We have previously found that adult onset disruption of CNTFR\u03b1 in facial MNs of \u201cfloxed CNTFR\u03b1\u201d mice by AAV\u2010Cre vector injection leads to significantly more MN loss than in identically treated controls. While indicating that CNTF receptors can promote adult MN survival, the data did not distinguish between potential roles in MN maintenance versus roles in protecting MNs from the injection associated trauma or the toxicity of the chronic Cre recombinase (Cre) produced by the AAV\u2010Cre. Here we used an inducible Cre gene construct to produce adult\u2010onset CNTFR\u03b1 disruption in facial MNs without the traumatic and toxic effects of the AAV\u2010Cre procedure. The MNs survive without CNTFR\u03b1, even when challenged by facial nerve crush or the injection\u2010associated trauma, thereby suggesting, in conjunction with our previous study, that endogenous CNTF receptor signaling can protect MNs against toxic insult, such as that produced by chronic Cre. The data also indicate that in vivo CNTF receptors play very different roles in adult and embryonic MNs. J. Comp. Neurol. 521:3217\u20133225, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23341","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T13:26:34Z","timestamp":1369142794000},"page":"3217-3225","source":"Crossref","is-referenced-by-count":3,"title":["The contribution of ciliary neurotrophic factor receptors to adult motor neuron survival in vivo is specific to insult type and distinct from that for embryonic motor neurons"],"prefix":"10.1002","volume":"521","author":[{"given":"Nancy","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology University of Cincinnati Cincinnati Ohio 45267\u20100576"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn E.","family":"Rydyznski","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology University of Cincinnati Cincinnati Ohio 45267\u20100576"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel P.","family":"Spearry","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology University of Cincinnati Cincinnati Ohio 45267\u20100576"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Robitz","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology University of Cincinnati Cincinnati Ohio 45267\u20100576"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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