{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:28:57Z","timestamp":1790623737859,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>An understanding of the anatomic distributions of major neurodegenerative disease lesions is important to appreciate the differential clinical profiles of these disorders and to serve as neuropathological standards for emerging molecular neuroimaging methods. To address these issues, here we present a comparative survey of the topographical distribution of the defining molecular neuropathological lesions among 10 neurodegenerative diseases from a large and uniformly assessed brain collection. Ratings of pathological severity in 16 brain regions from 671 cases with diverse neurodegenerative diseases are summarized and analyzed. These include: 1) amyloid\u2010\u03b2 and tau lesions in Alzheimer's disease; 2) tau lesions in three other tauopathies including Pick's disease, progressive supranuclear palsy and corticobasal degeneration; 3) \u03b1\u2010synuclein inclusion ratings in four synucleinopathies including Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies, and multiple system atrophy; and 4) TDP\u201043 lesions in two TDP\u201043 proteinopathies, including frontotemporal lobar degeneration associated with TDP\u201043 and amyotrophic lateral sclerosis. The data presented graphically and topographically confirm and extend previous pathological anatomic descriptions and statistical comparisons highlight the lesion distributions that either overlap or distinguish the diseases in each molecular disease category. J. Comp. Neurol. 521:4339\u20134355, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23430","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T18:30:14Z","timestamp":1374690614000},"page":"4339-4355","source":"Crossref","is-referenced-by-count":55,"title":["Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases"],"prefix":"10.1002","volume":"521","author":[{"given":"Steven E.","family":"Arnold","sequence":"first","affiliation":[{"name":"Penn Memory Center, Departments of Psychiatry and Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon B.","family":"Toledo","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine 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