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Many neurochemicals modulate olfactory information in the central nervous system, including the primary olfactory center of insects, the antennal lobe. The most diverse and versatile neurochemicals in the insect nervous system are found in the neuropeptides. In the present study, we analyzed neuropeptides in the antennal lobe of the yellow fever mosquito, <jats:italic>Aedes aegypti<\/jats:italic>, a major vector of arboviral diseases. Direct tissue profiling of the antennal lobe by matrix\u2010assisted laser desorption ionization time\u2010of\u2010flight (MALDI\u2010TOF) mass spectrometry indicated the presence of 28 mature products from 10 different neuropeptide genes. In addition, immunocytochemical techniques were used to describe the cellular location of the products of up to seven of these genes within the antennal lobe. Allatostatin A, allatotropin, SIFamide, FMRFamide\u2010related peptides, short neuropeptide F, myoinhibitory peptide, and tachykinin\u2010related peptides were found to be expressed in local interneurons and extrinsic neurons of the antennal lobe. Building on these results, we discuss the possible role of neuropeptide signaling in the antennal lobe of <jats:italic>Ae. aegypti<\/jats:italic>. J. Comp. Neurol. 522:592\u2013608, 2014. \u00a9 2013 The Authors. The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23434","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T20:42:49Z","timestamp":1375130569000},"page":"592-608","source":"Crossref","is-referenced-by-count":48,"title":["Neuropeptides in the antennal lobe of the yellow fever mosquito, <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"522","author":[{"given":"K.P.","family":"Siju","sequence":"first","affiliation":[{"name":"Unit of Chemical Ecology Department of Plant Protection Biology Swedish University of Agricultural Sciences 230 53 Alnarp Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Reifenrath","sequence":"additional","affiliation":[{"name":"Department of Biology Animal Physiology Philipps\u2010University 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Scheiblich","sequence":"additional","affiliation":[{"name":"Department of Biology Animal Physiology Philipps\u2010University 35032 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Neupert","sequence":"additional","affiliation":[{"name":"Biocenter University of Cologne 50674 Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Predel","sequence":"additional","affiliation":[{"name":"Biocenter University of Cologne 50674 Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill S.","family":"Hansson","sequence":"additional","affiliation":[{"name":"Unit of Chemical Ecology Department of Plant Protection Biology Swedish University of Agricultural Sciences 230 53 Alnarp Sweden"},{"name":"Department of Evolutionary Neuroethology Max Planck Institute for Chemical Ecology 07745 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Schachtner","sequence":"additional","affiliation":[{"name":"Unit of Chemical Ecology Department of Plant Protection Biology Swedish University of Agricultural Sciences 230 53 Alnarp Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rickard","family":"Ignell","sequence":"additional","affiliation":[{"name":"Unit of Chemical Ecology Department of Plant Protection Biology Swedish University of Agricultural Sciences 230 53 Alnarp Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0318-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(94)90158-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22405"},{"key":"e_1_2_8_5_1","volume-title":"Sensory reception and behaviour","author":"Clements AN","year":"1999"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05786.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/44.4.617"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-1133-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asd.2012.02.005"},{"key":"e_1_2_8_10_1","first-page":"181","volume-title":"Neuroactive substances in the antennal lobe. 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