{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:51:43Z","timestamp":1790049103582,"version":"4.0.1"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2014,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The insular cortex plays important roles in vocal communication, but the origin of auditory input to the insular cortex has not been fully clarified. Here we studied the auditory thalamic input to the insular cortex using mice as a model system. An insular auditory field (IAF) has recently been identified in mice. By using retrograde neuronal tracing, we identified auditory thalamic neurons projecting to the IAF, primary auditory cortex (AI), and anterior auditory field (AAF). After mapping the IAF, AAF, and AI by using optical imaging, we injected a distinct fluorescent tracer into each of the three fields at frequency\u2010matched locations. Tracer injection into the IAF resulted in retrogradely labeled cells localized ventromedially in the lemniscal division, i.e., the ventral subdivision of the medial geniculate body (MGv). Cells retrogradely labeled by injections into the AAF were primarily found in the medial half of the MGv, whereas those from AI injections were located in the lateral half, although some of these two subsets were intermingled within the MGv. Interestingly, retrogradely labeled cells projecting to the IAF showed virtually no overlap with those projecting to the AAF or the AI. Dual tracer injections into two sites responding to low\u2010 and high\u2010frequency tones within each of the three auditory fields demonstrated topographic organizations in all three thalamocortical projections. These results indicate that the IAF receives thalamic input from the MGv in a topographic manner, and that the MGv\u2013IAF projection is parallel to the MGv\u2013AAF and MGv\u2013AI projections. J. Comp. Neurol. 522:1373\u20131389, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23491","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T05:09:58Z","timestamp":1383282598000},"page":"1373-1389","source":"Crossref","is-referenced-by-count":49,"title":["The insular auditory field receives input from the lemniscal subdivision of the auditory thalamus in mice"],"prefix":"10.1002","volume":"522","author":[{"given":"Makoto","family":"Takemoto","sequence":"first","affiliation":[{"name":"Department of Sensory and Cognitive Physiology Graduate School of Medical Sciences Kumamoto University umamoto 860\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Sensory and Cognitive Physiology Graduate School of Medical Sciences Kumamoto University umamoto 860\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Sensory and Cognitive Physiology Graduate School of Medical Sciences Kumamoto University umamoto 860\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Sensory and Cognitive Physiology Graduate School of Medical Sciences Kumamoto University umamoto 860\u20108556 Japan"},{"name":"Program for Leading Graduate Schools Health Life Science: Interdisciplinary and Globally Oriented (HIGO) Program, Kumamoto University Kumamoto 860\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1972.35.3.365"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1789"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.12.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04930.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2007.02.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.11.037"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(03)00172-3"},{"key":"e_1_2_8_9_1","article-title":"Involvement of insular auditory cortex in negative affective ultrasonic vocal communication in rats","author":"Benison AM","year":"2012","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000038905.75660.BD"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4270-08.2008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.93"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00226-3"},{"key":"e_1_2_8_15_1","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin KBJ","year":"1997"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903490204"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.04.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90550-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902150203"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0065-12.2012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1407"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5333-10.2011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903620204"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1611-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001113)427:2<302::AID-CNE10>3.0.CO;2-J"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01173.2003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902270405"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.1.309"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)36029-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1989.tb00791.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.22.11793"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05519.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.01.032"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1985.tb37611.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902640110"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21611"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh006"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.06.062"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00751.2002"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21602"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.07.009"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902350403"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903180104"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902270112"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53860-4.00007-6"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00689.2006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040215"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01298.2006"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7701330"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4089-08.2009"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270677"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn054"},{"key":"e_1_2_8_54_1","first-page":"127","volume-title":"Biological and biochemical bases of behavior","author":"Rose JE","year":"1958"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07926.x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90258-D"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003590050140"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22345"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22501"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1310-12.2012"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017832"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10905"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.09.010"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(84)90031-5"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-12-02629.1983"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00216-0"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00217-2"},{"key":"e_1_2_8_68_1","first-page":"165","volume-title":"Neural mechanisms of the auditory and vestibular system","author":"Woolsey CN.","year":"1960"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.23491","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.23491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:06:18Z","timestamp":1696629978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.23491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,4,15]]}},"alternative-id":["10.1002\/cne.23491"],"URL":"https:\/\/doi.org\/10.1002\/cne.23491","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]}}}