{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:07:39Z","timestamp":1791518859223,"version":"4.3.4"},"reference-count":131,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2014,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Down syndrome (DS), trisomy 21, is a multifaceted condition marked by intellectual disability and early presentation of Alzheimer's disease (AD) neuropathological lesions including degeneration of the basal forebrain cholinergic neuron (BFCN) system. Although DS is diagnosable during gestation, there is no treatment option for expectant mothers or DS individuals. Using the Ts65Dn mouse model of DS that displays age\u2010related degeneration of the BFCN system, we investigated the effects of maternal choline supplementation on the BFCN system in adult Ts65Dn mice and disomic (2N) littermates at 4.3\u20137.5 months of age. Ts65Dn dams were maintained on a choline\u2010supplemented diet (5.1 g\/kg choline chloride) or a control, unsupplemented diet with adequate amounts of choline (1 g\/kg choline chloride) from conception until weaning of offspring; post weaning, offspring were fed the control diet. Mice were transcardially perfused with paraformaldehyde, and brains were sectioned and immunolabeled for choline acetyltransferase (ChAT) or p75\u2010neurotrophin receptor (p75<jats:sup>NTR<\/jats:sup>). BFCN number and size, the area of the regions, and the intensity of hippocampal labeling were determined. Ts65Dn\u2010unsupplemented mice displayed region\u2010 and immunolabel\u2010dependent increased BFCN number, larger areas, smaller BFCNs, and overall increased hippocampal ChAT intensity compared with 2N unsupplemented mice. These effects were partially normalized by maternal choline supplementation. Taken together, the results suggest a developmental imbalance in the Ts65Dn BFCN system. Early maternal\u2010diet choline supplementation attenuates some of the genotype\u2010dependent alterations in the BFCN system, suggesting this naturally occurring nutrient as a treatment option for pregnant mothers with knowledge that their offspring is trisomy 21. J. Comp. Neurol. 522:1390\u20131410, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23492","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T09:12:59Z","timestamp":1383297179000},"page":"1390-1410","source":"Crossref","is-referenced-by-count":45,"title":["Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young\u2010adult Ts65Dn and disomic mice"],"prefix":"10.1002","volume":"522","author":[{"given":"Christy M.","family":"Kelley","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Powers","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University Ithaca New York 14853"},{"name":"Department of Psychology Cornell University Ithaca New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University Ithaca New York 14853"},{"name":"Department of Psychology Cornell University Ithaca New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Ash","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University Ithaca New York 14853"},{"name":"Department of Psychology Cornell University Ithaca New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Center for Dementia Research Nathan Kline Institute Orangeburg NY 10962"},{"name":"Department of Psychiatry New York University Langone Medical Center New York New York 10016"},{"name":"Department of Physiology &amp; Neuroscience New York University Langone Medical Center New York New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Strupp","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University Ithaca New York 14853"},{"name":"Department of Psychology Cornell University Ithaca New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott J.","family":"Mufson","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056997"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(87)90028-9"},{"key":"e_1_2_9_4_1","first-page":"133","article-title":"Growth and development of the brain in Down syndrome","volume":"373","author":"Becker L","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-08164.2001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64020749.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(98)80010-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(89)90110-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180306"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06788.2003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.3.349"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017371"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.11.026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03769.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.8.2393S"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181219298"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301535"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01178228"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.4.263"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90075-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.15.1401"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10069"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.2.424"},{"key":"e_1_2_9_24_1","first-page":"241","article-title":"Epilogue: toward the twenty\u2010first century with Down syndrome\u2014a personal view of how far we have come and of how far we can reasonably expect to go","volume":"393","author":"Epstein CJ","year":"1995","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1053"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0564fje"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00769-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200512000-00004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03764.x"},{"key":"e_1_2_9_30_1","volume-title":"Stereology for biological research with a focus on neuroscience","author":"Glasser J","year":"2007"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0043-31442005000600002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7289"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(02)00884-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1988.tb04609.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1999.00457.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61676-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.104"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)38548-0"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30184"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540280065020"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.14.9002559"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00321-7"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13333"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(03)00005-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2003-5106"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"lb219","DOI":"10.1096\/fasebj.21.6.LB46-c","article-title":"Choline in the diets of the US population: NHANES, 2003\u20132004","volume":"21","author":"Jensen HH","year":"2007","journal-title":"FASEB J"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2003)108<367:EODOCF>2.0.CO;2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90182-M"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1951304"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a107462"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-102097"},{"key":"e_1_2_9_52_1","article-title":"Sex differences in cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease","author":"Kelley CM","year":"2013","journal-title":"Brain Pathol"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb01864.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32953"},{"key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1523\/JNEUROSCI.09-09-02999.1989","article-title":"Localization and development of nerve growth factor\u2010sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex","volume":"9","author":"Koh S","year":"1989","journal-title":"J Neurosci"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.41.1.g"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705539200"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04533"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-01-00001.1983"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00785.2003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3233\/JAD-2008-13307","article-title":"Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome","volume":"13","author":"Liang Z","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2144\/03356st02","article-title":"Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome","volume":"35","author":"Liu DP","year":"2003","journal-title":"Biotechniques"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.021"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.03.036"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.7.1133"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0145-6_21"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3104\/reports.317"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1984.tb00351.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129275.13169.BE"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90184-0"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02599-X"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199709080-00005"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00105-4"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00069-1"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420210405"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.103.6.1234"},{"key":"e_1_2_9_77_1","first-page":"7","article-title":"Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age\u2010related dementia","volume":"1","author":"Meck WH","year":"2007","journal-title":"Front Integr Neurosci"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0877fje"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902140206"},{"key":"e_1_2_9_80_1","article-title":"Memantine for dementia in people with Down syndrome","author":"Mohan M","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0019590"},{"key":"e_1_2_9_82_1","volume-title":"Principles and practices of unbiased stereology: an introduction for bioscientists","author":"Mouton PR","year":"2002"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(89)90124-6"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199110000-00004"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901710409"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.02.003"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.08.042"},{"key":"e_1_2_9_88_1","volume-title":"Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline","author":"National Academy of Sciences and Institute of Medicine (IOM)","year":"1998"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02414.x"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.06.004"},{"key":"e_1_2_9_91_1","volume-title":"The mouse brain in stereotaxic coordinate","author":"Paxinos G","year":"2001"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.077"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430316"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.587"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.4.1790"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21546"},{"key":"e_1_2_9_97_1","author":"Rasband WS","year":"1997","journal-title":"U.S. National Institutes of Health"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-177"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.050898"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90083-6"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.022"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000258"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02900-1"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.10.003"},{"key":"e_1_2_9_105_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3758\/BF03333077","article-title":"Indirect effects of peri\u2010 and postnatal choline treatment on place\u2010learning abilities in rat","volume":"23","author":"Schenk F","year":"1995","journal-title":"Psychobiology"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690107"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.741185.x"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.017"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4970-06.2007"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh187"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.896"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31790"},{"key":"e_1_2_9_113_1","volume-title":"Applications of unbiased stereology to neural systems","author":"Stereology Resource Center","year":"2008"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902670205"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00074-1"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.1.120"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2009.07.002"},{"key":"e_1_2_9_118_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2013.04.016","article-title":"Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome","volume":"52","author":"Velazquez R","year":"2013","journal-title":"Neurobiol Dis"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-229"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/416535a"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.03.009"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.15.5293-5300.2003"},{"key":"e_1_2_9_123_1","first-page":"135","article-title":"Differential susceptibility to neurofibrillary pathology among patients with Down syndrome","volume":"7","author":"Wegiel J","year":"1996","journal-title":"Dementia"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07955.x"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00229-7"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.7.957"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.08.074"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1159\/000192998"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92137-6"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91179-4"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00349-X"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.14.070194.001413"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.23492","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.23492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T02:06:32Z","timestamp":1696644392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.23492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":131,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,4,15]]}},"alternative-id":["10.1002\/cne.23492"],"URL":"https:\/\/doi.org\/10.1002\/cne.23492","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]}}}