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By using retrograde labeling and digital reconstruction, we investigated the morphometry and topology of the dendritic trees of these neurons and the changes induced by long\u2010term experience\u2010dependent plasticity in adult male rats. Primary afferent input was either eliminated by transection of the right infraorbital nerve (IoN), or selectively altered by repeated whisker clipping on the right side. These neurons do not display asymmetries between sides in basic metric and topologic parameters (global number of trees, nodes, spines, or dendritic ends), although neurons on the left tend to have longer terminal segments. Ipsilaterally, both deafferentation (IoN transection) and deprivation (whisker trimming) reduced the density of spines, and the former also caused a global increase in total dendritic length and a relative increase in more complex arbors. Contralaterally, deafferentation reduced more complex dendritic trees, and caused a moderate decline in dendritic length and spatial reach, and a loss of spines in number and density. Deprivation caused a similar, but more profound, effect on spines. Our findings provide original quantitative descriptions of a scarcely known cell population, and show that denervation\u2010 or deprivation\u2010derived plasticity is expressed not only by neurons at higher levels of the sensory pathways, but also by neurons in key subcortical circuits for sensory processing. J. Comp. Neurol. 522:1597\u20131617, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23494","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T09:13:49Z","timestamp":1383297229000},"page":"1597-1617","source":"Crossref","is-referenced-by-count":6,"title":["Trigeminal intersubnuclear neurons: Morphometry and input\u2010dependent structural plasticity in adult rats"],"prefix":"10.1002","volume":"522","author":[{"given":"Yasmina B.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology, &amp; Neuroscience Autonoma University of Madrid 28029 Madrid Spain"},{"name":"Department of Anatomy Francisco de Vitoria University 28223 Pozuelo de Alarc\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Negredo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology, &amp; Neuroscience Autonoma University of Madrid 28029 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Villacorta\u2010Atienza","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics Complutense University of Madrid School of Mathematics 28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Avenda\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology, &amp; 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