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We have developed and characterized a new set of affinity\u2010purified guinea pig and rabbit antibodies against RNA\u2010binding protein with multiple splicing (RBPMS). On western blots these antibodies recognize a single band at \u301c24 kDa, corresponding to RBPMS, and they strongly label RGC and displaced RGC (dRGC) somata in mouse, rat, guinea pig, rabbit, and monkey retina. RBPMS\u2010immunoreactive cells and RGCs identified by other techniques have a similar range of somal diameters and areas. The density of RBPMS cells in mouse and rat retina is comparable to earlier semiquantitative estimates of RGCs. RBPMS is mainly expressed in medium and large DAPI\u2010, DRAQ5\u2010, NeuroTrace\u2010 and NeuN\u2010stained cells in the ganglion cell layer (GCL), and RBPMS is not expressed in syntaxin (HPC\u20101)\u2010immunoreactive cells in the inner nuclear layer (INL) and GCL, consistent with their identity as RGCs, and not displaced amacrine cells. In mouse and rat retina, most RBPMS cells are lost following optic nerve crush or transection at 3 weeks, and all Brn3a\u2010, SMI\u201032\u2010, and melanopsin\u2010immunoreactive RGCs also express RBPMS immunoreactivity. RBPMS immunoreactivity is localized to cyan fluorescent protein (CFP)\u2010fluorescent RGCs in the B6.Cg\u2010Tg(Thy1\u2010CFP)23Jrs\/J mouse line. These findings show that antibodies against RBPMS are robust reagents that exclusively identify RGCs and dRGCs in multiple mammalian species, and they will be especially useful for quantification of RGCs. J. Comp. Neurol. 522:1411\u20131443, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23521","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T05:02:30Z","timestamp":1386565350000},"page":"1411-1443","source":"Crossref","is-referenced-by-count":473,"title":["The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina"],"prefix":"10.1002","volume":"522","author":[{"given":"Allen R.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Neurobiology David Geffen School of Medicine at Los Angeles, University of California at Los Angeles Los Angeles California 90095\u20101763"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis P\u00e9rez","family":"de Sevilla M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurobiology David Geffen School of Medicine at Los Angeles, University of California at Los Angeles Los Angeles California 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