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In the mouse vibrissa system, trigeminal brainstem circuits are thought to mediate the first stage of vibrissa scanning control via sensory feedback that provides reflexive protraction in response to stimulation. However, these circuits are not well defined. Here we describe a complete disynaptic sensory receptor\u2010to\u2010muscle circuit for positive feedback in vibrissa movement. We identified a novel region of trigeminal brainstem, <jats:italic>spinal trigeminal nucleus pars muralis<\/jats:italic>, which contains a class of vGluT2+ excitatory projection neurons involved in vibrissa motor control. Complementary single\u2010 and dual\u2010labeling with traditional and virus tracers demonstrate that these neurons both receive primary inputs from vibrissa sensory afferent fibers and send monosynaptic connections to facial nucleus motoneurons that directly innervate vibrissa musculature. These anatomical results suggest a general role of disynaptic architecture in fast positive feedback for motor output that drives active sensation. J. Comp. Neurol. 523:921\u2013942, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23724","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T05:43:27Z","timestamp":1418363007000},"page":"921-942","source":"Crossref","is-referenced-by-count":20,"title":["Feedback in the brainstem: An excitatory disynaptic pathway for control of whisking"],"prefix":"10.1002","volume":"523","author":[{"given":"David W.","family":"Matthews","sequence":"first","affiliation":[{"name":"Graduate Program in Neuroscience University of California, San Diego La Jolla CA 92093 USA"},{"name":"Department of Physics University of California, San Diego La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Centre de Recherche Universit\u00e9 Laval Robert\u2010Giffard Qu\u00e9bec City Qu\u00e9bec G1J 2R3 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Morphological Brain Science Graduate School of Medicine Kyoto University Kyoto 606\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Moore","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience University of California, San Diego La Jolla CA 92093 USA"},{"name":"Department of Physics University of California, San Diego La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Duke University Medical Center Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey J.","family":"Karten","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience University of California, San Diego La Jolla CA 92093 USA"},{"name":"Department of Neuroscience University of California, San Diego, School of Medicine La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kleinfeld","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience University of California, San Diego La Jolla CA 92093 USA"},{"name":"Department of Physics University of California, San Diego La Jolla CA 92093 USA"},{"name":"Section of Neurobiology University of California, San Diego La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.076034"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00155-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902110108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/apha.1953.29.s106.209","article-title":"On the central course of afferent fibres in the trigeminal, facial, glossophryngeal, and vagal nerves and their nuclei in the mouse","volume":"29","author":"Astrom KE","year":"1953","journal-title":"Acta Physiol Scand"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20778"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1523\/JNEUROSCI.4805-09.2010","article-title":"Feedforward inhibition determines the angular tuning of vibrissal responses in the principal trigeminal nucleus","volume":"30","author":"Bellavance MA","year":"2010","journal-title":"J Neurosci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2007.07.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195159561.003.0003"},{"key":"e_1_2_9_11_1","first-page":"704","volume-title":"Chapter XXXI. 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