{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:58:07Z","timestamp":1774940287076,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["DG-R87150"],"award-info":[{"award-number":["DG-R87150"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Peripheral arterial chemoreceptors have been isolated to the common carotid artery, aorta, and pulmonary artery of turtles. However, the putative neurotransmitters associated with these chemoreceptors have not yet been described. The goal of the present study was to determine the neurochemical content, innervations, and distribution of putative oxygen\u2010sensing cells in the central vasculature of turtles and to derive homologies with peripheral arterial chemoreceptors of other vertebrates. We used tract tracing together with immunohistochemical markers for cholinergic cells (vesicular acetylcholine transporter [VAChT]), tyrosine hydroxylase (TH; the rate\u2010limiting enzyme in catecholamine synthesis), and serotonin (5HT) to identify putative oxygen\u2010sensing cells and to determine their anatomical relation to branches of the vagus nerve (Xth cranial nerve). We found potential oxygen\u2010sensing cells in all three chemosensory areas innervated by branches of the Xth cranial nerve. Cells containing either 5HT or VAChT were found in all three sites. The morphology and size of these cells resemble glomus cells found in amphibians, mammals, tortoises, and lizards. Furthermore, we found populations of cholinergic cells located at the base of the aorta and pulmonary artery that are likely involved in efferent regulation of vessel resistance. Catecholamine\u2010containing cells were not found in any of the putative chemosensitive areas. The presence of 5HT\u2010 and VAChT\u2010immunoreactive cells in segments of the common carotid artery, aorta, and pulmonary artery appears to reflect a transition between cells containing the major neurotransmitters seen in fish (5HT) and mammals (ACh and adenosine). J. Comp. Neurol. 523:1399\u20131418, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23743","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T06:56:56Z","timestamp":1421218616000},"page":"1399-1418","source":"Crossref","is-referenced-by-count":9,"title":["Distribution and innervation of putative peripheral arterial chemoreceptors in the red\u2010eared slider (<i>Trachemys scripta elegans<\/i>)"],"prefix":"10.1002","volume":"523","author":[{"given":"Catalina","family":"Reyes","sequence":"first","affiliation":[{"name":"Department of Zoology University of British Columbia Vancouver British Columbia, Vancouver Canada V6T 1Z4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina Y.","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Melbourne Parkville Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Milsom","sequence":"additional","affiliation":[{"name":"Department of Zoology University of British Columbia Vancouver British Columbia, Vancouver Canada V6T 1Z4"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"535","article-title":"The topographical anatomy and blood supply of the carotid body region of the domestic fowl","volume":"126","author":"Abdel\u2010Magied E","year":"1978","journal-title":"J Anat"},{"key":"e_1_2_9_3_1","volume-title":"The comparative morphology of the carotid body and carotid sinus","author":"Adams WE","year":"1958"},{"key":"e_1_2_9_4_1","first-page":"28","article-title":"The carotid sinus\u2010carotid body problem in the Chelonia (with a note on a foramen of Panizza in Dermochelys)","volume":"139","author":"Adams WE","year":"1962","journal-title":"Arch Intl Pharmacodyn Ther"},{"key":"e_1_2_9_5_1","volume-title":"The carotid sinus and the cerebral circulation","author":"Ask\u2010Upmark E","year":"1935"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1201\/b10181-5","volume-title":"airway chemoreceptors in the vertebrates: structure, evolution and function","author":"Bailly Y","year":"2009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(77)90101-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/27.1.111"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218368"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.3.839"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/27.1.5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(93)90071-H"},{"key":"e_1_2_9_14_1","first-page":"231","article-title":"Cardio\u2010ventilatory control in rainbow trout: I","volume":"100","author":"Burleson M","year":"1995","journal-title":"Pharmacology of branchial, oxygen\u2010sensitive chemoreceptors. Respir Physiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.01.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307057"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.015248"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15.2.65"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1052060108"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.6.1342"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.4.931"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(69)90055-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1201\/b10181-12","volume-title":"Airway chemoreceptors in the vertebrates: structure, evolution and function","author":"Garcia LMP","year":"2009"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970401)37:1<13::AID-JEMT3>3.0.CO;2-X"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21131"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.67.6.30163900"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(82)90076-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90014-9"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216888"},{"key":"e_1_2_9_31_1","first-page":"263","article-title":"Fine structure of the chemoreceptor cell in the amphibian carotid labyrinth","volume":"104","author":"Ishii K","year":"1969","journal-title":"J Anat"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.88.103"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90064-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(85)90017-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10680"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10181-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4584-1_3"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.069294"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.151.395"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051970205"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.4.1467"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.1.55"},{"key":"e_1_2_9_43_1","first-page":"221","volume-title":"Physiology of the peripheral arterial chemoreceptors","author":"Lahiri S","year":"1983"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1139\/z80-129"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.02.007"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1139\/z77-049"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22762"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22694"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(91)90196-Z"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.04.008"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.049312"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21705"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/rr51"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.06.019"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.031922"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00034.2013"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23640"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/200492b0"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051220204"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21105"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.079657"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.64.2.323"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2006.12.010"},{"key":"e_1_2_9_65_1","first-page":"97","article-title":"Chemoreceptor modulation of endogenous respiratory rhythms in vertebrates","volume":"259","author":"Smatresk N","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220304"},{"key":"e_1_2_9_67_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/cne.22080","article-title":"Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: effect of olfactory ensheathing glia","volume":"15","author":"Takeoka A","year":"2009","journal-title":"J Comp Neurol"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.2001.tb00044.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2004.01.002"},{"key":"e_1_2_9_70_1","first-page":"151","volume-title":"Environmental physiology of the amphibian","author":"West NH","year":"1992"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-6395.1992.tb01185.x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00158286"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970401)37:1<4::AID-JEMT2>3.0.CO;2-R"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.06.024"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.23743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.23743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T13:15:02Z","timestamp":1696598102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.23743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,23]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,6,15]]}},"alternative-id":["10.1002\/cne.23743"],"URL":"https:\/\/doi.org\/10.1002\/cne.23743","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,23]]}}}