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Specifically, in early\u2010deaf cats, the anterior auditory field (AAF) is unresponsive to auditory stimuli but can be activated by somatosensory and visual stimuli. Similarly, AAF neurons respond to tactile input in adult\u2010deafened animals. To examine anatomical changes that may underlie this functional adaptation following early or late deafness, afferent projections to AAF were examined in hearing cats, and cats with early\u2010 or adult\u2010onset deafness. Unilateral deposits of biotinylated dextran amine were made in AAF to retrogradely label cortical and thalamic afferents to AAF. In early\u2010deaf cats, ipsilateral neuronal labeling in visual and somatosensory cortices increased by 329% and 101%, respectively. The largest increases arose from the anterior ectosylvian visual area and the anterolateral lateral suprasylvian visual area, as well as somatosensory areas S2 and S4. Consequently, labeling in auditory areas was reduced by 36%. The age of deafness onset appeared to influence afferent connectivity, with less marked differences observed in late\u2010deaf cats. Profound changes to visual and somatosensory afferent connectivity following deafness may reflect corticocortical rewiring affording acoustically deprived AAF with cross\u2010modal functionality. J. Comp. Neurol. 523:1925\u20131947, 2015 \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23771","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T08:29:01Z","timestamp":1426148941000},"page":"1925-1947","source":"Crossref","is-referenced-by-count":57,"title":["Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, following early\u2010 and late\u2010onset deafness"],"prefix":"10.1002","volume":"523","author":[{"given":"Carmen","family":"Wong","sequence":"first","affiliation":[{"name":"Cerebral Systems Laboratory, University of Western Ontario London Ontario N6A 5K8 Canada"},{"name":"Graduate Program in Neuroscience University of Western Ontario London Ontario N6A 5K8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Chabot","sequence":"additional","affiliation":[{"name":"Cerebral Systems Laboratory, University of Western Ontario London Ontario 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