{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:16:32Z","timestamp":1787163392266,"version":"build-2736575974"},"reference-count":105,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS 046367"],"award-info":[{"award-number":["NS 046367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Upper extremity hemiplegia is a common consequence of unilateral cortical stroke. Understanding the role of the unaffected cerebral hemisphere in the motor recovery process has been encouraged, in part, by the presence of ipsilateral corticospinal projections (iCSP). We examined the neuroplastic response of the iCSP from the contralesional primary motor cortex (cM1) hand\/arm area to spinal levels C5\u2013T1 after spontaneous long\u2010term recovery from isolated frontal lobe injury and isolated frontoparietal injury. High\u2010resolution tract tracing, stereological, and behavioral methodologies were applied. Recovery from frontal motor injury resulted in enhanced numbers of terminal labeled boutons in the iCSP from cM1 compared with controls. Increases occurred in lamina VIII and the adjacent ventral sectors of lamina VII, which are involved in axial\/proximal limb sensorimotor processing. Larger frontal lobe lesions were associated with greater numbers of terminal boutons than smaller frontal lobe lesions. In contrast, frontoparietal injury blocked this response; total bouton number was similar to controls, demonstrating that disruption of somatosensory input to one hemisphere has a suppressive effect on the iCSP from the nonlesioned hemisphere. However, compared with controls, elevated bouton numbers occurred in lamina VIII, at the expense of lamina VII bouton labeling. Lamina IX boutons were also elevated in two frontoparietal lesion cases with extensive cortical injury. Because laminae VIII and IX collectively harbor axial, proximal, and distal motoneurons, therapeutic intervention targeting the ipsilateral corticospinal linkage from cM1 may promote proximal, and possibly distal, upper\u2010limb motor recovery following frontal and frontoparietal injury. J. Comp. Neurol. 524:380\u2013407, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.23861","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T05:04:51Z","timestamp":1438232691000},"page":"380-407","source":"Crossref","is-referenced-by-count":39,"title":["Frontal and frontoparietal injury differentially affect the ipsilateral corticospinal projection from the nonlesioned hemisphere in monkey (\n                    <i>Macaca mulatta<\/i>\n                    )"],"prefix":"10.1002","volume":"524","author":[{"given":"R.J.","family":"Morecraft","sequence":"first","affiliation":[{"name":"Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences The University of South Dakota Sanford School of Medicine Vermillion South Dakota 57069"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences, Laboratory of Neurological 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