{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:46:36Z","timestamp":1791305196738,"version":"4.3.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["10468140 (to D.H.R.)"],"award-info":[{"award-number":["10468140 (to D.H.R.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The claustrum has been the subject of intense research interest in recent years, driven in large part by its extensive connections with various regions of the cerebral cortex and by hypotheses surrounding its possible role in multimodal sensory and\/or sensory\u2013emotional integration. Here we employed neuroanatomical tracers to map projections from the claustrum\u2013insular region to the medial prefrontal and anterior cingulate cortex of the common marmoset (\n                    <jats:italic>Callithrx jacchus<\/jats:italic>\n                    ). These areas were selected based on their identification as \u201chub\u201d areas of the default mode and cortical salience networks, respectively. Microinjections of fluorescent tracers, along with gold\u2010nanoparticle\u2010conjugated cholera toxin B\u2010subunit and biotinylated dextran amine, were placed in subdivisions of the anterior cingulate area 24b\/c and in medial prefrontal areas 32 and 32V. The resulting distribution of transported label showed rostral\u2010caudal and dorsal\u2010ventral topographic arrangement of claustrum connections and clear rostral\u2010caudal topography of insular projections. Medial prefrontal connections were restricted mainly to a ventromedial strip located in the rostral half of the claustrum, with a second, smaller patch of cells in the caudal, ventrolateral portion. In contrast, injections into area 24 yielded dense, widespread connections from the dorsal claustrum, extending along its entire rostral\u2010caudal length. Projections from the \u201cclassical\u201d agranular, disgranular, and granular insular areas were sparse or nonexistent in areas 32 and 32V, with progressively increasing connections observed in more caudal tracer injections (i.e., in subdivisions of area 24). Transported label was observed in rostral peri\u2010insular areas orbital periallocortex, orbital proisocortex, and insular proisocortex following all prefrontal injections. These data provide a structural connectivity foundation for interpretation of functional imaging studies, which often indicate activity in the \u201canterior insula\u201d that may arise, in part, from claustrum and\/or peri\u2010insular projections to the anterior cingulate and medial prefrontal cortices. J. Comp. Neurol. 525:1421\u20131441, 2017. \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/cne.24009","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T18:59:20Z","timestamp":1459623560000},"page":"1421-1441","source":"Crossref","is-referenced-by-count":61,"title":["Topography of claustrum and insula projections to medial prefrontal and anterior cingulate cortices of the common marmoset (\n                    <i>Callithrix jacchus<\/i>\n                    )"],"prefix":"10.1002","volume":"525","author":[{"given":"David H.","family":"Reser","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University Clayton Victoria 3800 Australia"},{"name":"Neuroscience Program, Biomedicine Research Institute Monash University Clayton Victoria 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Majka","sequence":"additional","affiliation":[{"name":"Department of 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