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The main olfactory epithelium (MOE) is an excellent model to study neurogenesis in the adult nervous system. Analyses of homeobox genes during development show that some of these genes are involved in the formation and establishment of cell diversity in the MOE. Moreover, the mechanisms of expression of odorant receptors (ORs) constitute one of the biggest enigmas in the field. Analyses of OR promoters revealed the presence of homeodomain binding sites in their sequences. Here we characterize the expression patterns of a set of 49 homeobox genes in the MOE with <jats:italic>in situ<\/jats:italic> hybridization. We found that seven of them (<jats:italic>Dlx3<\/jats:italic>, <jats:italic>Dlx5<\/jats:italic>, <jats:italic>Dlx6<\/jats:italic>, <jats:italic>Msx1<\/jats:italic>, <jats:italic>Meis1<\/jats:italic>, <jats:italic>Isl1<\/jats:italic>, and <jats:italic>Pitx1<\/jats:italic>) are zonally expressed. The homeobox gene <jats:italic>Emx1<\/jats:italic> is expressed in three <jats:italic>guanylate cyclase<\/jats:italic><jats:sup>+<\/jats:sup> populations, two located in the MOE and the third one in an olfactory subsystem known as Gr\u00fcneberg ganglion located at the entrance of the nasal cavity. The homeobox gene <jats:italic>Tshz1<\/jats:italic> is expressed in a unique patchy pattern across the MOE. Our findings provide new insights to guide functional studies that aim to understand the complexity of transcription factor expression and gene regulation in the MOE. J. Comp. Neurol. 524:2713\u20132739, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.24051","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T15:38:48Z","timestamp":1464709128000},"page":"2713-2739","source":"Crossref","is-referenced-by-count":22,"title":["Expression of homeobox genes in the mouse olfactory epithelium"],"prefix":"10.1002","volume":"524","author":[{"given":"Marta","family":"Parrilla","sequence":"first","affiliation":[{"name":"Max Planck Institut f\u00fcr Biophysik Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Chang","sequence":"additional","affiliation":[{"name":"Max Planck Institut f\u00fcr Biophysik Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Degl'Innocenti","sequence":"additional","affiliation":[{"name":"Max Planck Institut f\u00fcr Biophysik Frankfurt am Main Germany"},{"name":"Unit\u00e0 di Biologia Cellulare e dello Sviluppo, Dipartimento di Biologia Universit\u00e0 di Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Omura","sequence":"additional","affiliation":[{"name":"Max Planck Institut f\u00fcr Biophysik Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26083"},{"key":"e_1_2_9_3_1","unstructured":"Allen Developing Mouse Brain Atlas. 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