{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:29:07Z","timestamp":1778030947382,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001288","name":"Parkinson's Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Clinical trials testing the hypothesis that fetal dopamine grafts would provide antiparkinsonian benefit in patients who had already developed side effects from their long\u2010term use of L\u2010dopa revealed, in some cases, the presence of dyskinesias even in the absence of L\u2010dopa. The form, intensity, and frequency of these dyskinesias were quite variable, but their manifestation slowed the clinical development of cell replacement therapies. Rodent models of graft\u2010induced dyskinesias (GIDs) have been proposed, but their accuracy in modeling GIDs has been questioned because they usually require amphetamine for their presentation. The present study attempted to model GIDs in parkinsonian monkeys and, for the first time, to test the effect of grafts on previously dyskinetic monkeys. Toward this end, monkeys were rendered parkinsonian with n\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) and dyskinetic with levodopa. They then received intraputamenal grafts of fetal dopaminergic cells, control cerebellar cells, or vehicle bilaterally and were studied for 18 months. Dopaminergic cells were grafted in a manner designed to produce either \u201chot spot\u201d or \u201cwidespread\u201d striatal innervation. Although levodopa\u2010induced dyskinesias could be elicited postoperatively, GIDs were never observed in any animal at any time after grafting. Grafted monkeys were also challenged with levodopa but did not show any greater responses to these challenges than before grafting. These studies support the development of future dopamine neuron cell transplantation therapy\u2010based approaches, indicating that in relevant primate models with appropriate cell preparation methodology, with successful graft survival and putamenal dopamine innervation, there is no evidence of graft\u2010induced dyskinesias. J. Comp. Neurol. 525:498\u2013512, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/cne.24081","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T09:51:50Z","timestamp":1468576310000},"page":"498-512","source":"Crossref","is-referenced-by-count":9,"title":["Parkinsonian monkeys with prior levodopa\u2010induced dyskinesias followed by fetal dopamine precursor grafts do not display graft\u2010induced dyskinesias"],"prefix":"10.1002","volume":"525","author":[{"given":"Jeffrey H.","family":"Kordower","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Vinuela","sequence":"additional","affiliation":[{"name":"Department of Neurology McLean Hospital, Harvard Medical School Belmont Massachusetts 02478"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Isacson","sequence":"additional","affiliation":[{"name":"Department of Neurology McLean Hospital, Harvard Medical School Belmont Massachusetts 02478"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"D. Eugene","family":"Redmond","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neurosurgery Yale University New Haven Connecticut 06511"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01360.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02382808"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155957"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.09.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90014-L"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199707070-00032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.8.1421"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<459::AID-MDS1006>3.0.CO;2-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00564-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00437-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(82)90133-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn863"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0963-6897(97)86921-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2009.06.010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<203::AID-CNE6>3.0.CO;2-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.11.011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.06.011"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.03.014"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"S79","article-title":"Investigating levodopa\u2010induced dyskinesias in the parkinsonian primate","volume":"47","author":"Langston JW","year":"2000","journal-title":"Ann Neurol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10359"},{"key":"e_1_2_9_24_1","first-page":"497","article-title":"Immunohistochemical analysis of human lymphomas with monoclonal antibodies to B cell and Ia antigens reactive in paraffin sections","volume":"52","author":"Marder RJ","year":"1985","journal-title":"Lab Invest"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.029"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.8.1285"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2165"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10720"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59575-1.00009-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000976"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23743"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-298-4_21"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22000"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91839-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704091104"},{"key":"e_1_2_9_36_1","first-page":"510581","article-title":"Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain","volume":"20","author":"Saenz del Burgo L","year":"2008","journal-title":"J Comp Neurol"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.038"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90508-N"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1447-7_6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0963-6897(94)00035-I"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00214-5"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.24081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.24081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:28:34Z","timestamp":1694942914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.24081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2,15]]}},"alternative-id":["10.1002\/cne.24081"],"URL":"https:\/\/doi.org\/10.1002\/cne.24081","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]}}}