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OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using <jats:italic>Xenopus<\/jats:italic> tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating olfactory\u2010guided behavior. Tadpoles recover the ability to detect amino acids 4 days after bilateral olfactory nerve transection. Restoration of olfactory\u2010guided behavior depends on the efficient reinsertion of OSNs to the olfactory bulb. Presynaptic terminals of incipient synaptic contacts generate calcium transients in response to odors, triggering long lasting depolarization of olfactory glomeruli. The functionality of reconnected terminals relies on well\u2010defined readily releasable and cytoplasmic vesicle pools. The continuous growth of non\u2010compartmentalized axonal processes provides a vesicle reservoir to nascent release sites, which contrasts to the gradual development of cytoplasmic vesicle pools in conventional excitatory synapses. The immediate availability of fully functional synapses upon formation supports an age\u2010independent contribution of OSNs to the generation of odor maps.<\/jats:p>","DOI":"10.1002\/cne.24303","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:40:33Z","timestamp":1502959233000},"page":"3769-3783","source":"Crossref","is-referenced-by-count":12,"title":["Tight temporal coupling between synaptic rewiring of olfactory glomeruli and the emergence of odor\u2010guided behavior in <i>Xenopus<\/i> tadpoles"],"prefix":"10.1002","volume":"525","author":[{"given":"Beatrice","family":"Terni","sequence":"first","affiliation":[{"name":"Laboratory of Neurobiology Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona Barcelona Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pacciolla","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona Barcelona Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Masanas","sequence":"additional","affiliation":[{"name":"Bellvitge Biomedical Research Institute (IDIBELL) Barcelona Spain"},{"name":"Institut de Bioenginyeria de Catalunya (IBEC) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5577","authenticated-orcid":false,"given":"Pau","family":"Gorostiza","sequence":"additional","affiliation":[{"name":"Institut de Bioenginyeria de Catalunya (IBEC) Barcelona Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA) Barcelona Spain"},{"name":"Network Biomedic Research Center in Biophysics, Bioengineering and Nanomedicine (CIBER\u2010bbn) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-6782","authenticated-orcid":false,"given":"Artur","family":"Llobet","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona Barcelona Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL) Barcelona Spain"},{"name":"Institute of Neurosciences, University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)80026-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02185"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23835"},{"issue":"5","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1523\/JNEUROSCI.20-05-02011.2000","article-title":"Long\u2010lasting depolarizations in mitral cells of the rat olfactory bulb","volume":"20","author":"Carlson G. 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