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This RFamide neuropeptide has neuromodulatory functions and controls the synthesis and\/or release of gonadotropin\u2010releasing hormone (GnRH) and gonadotropins. Although teleosts represent about half of all living vertebrates, scientific and technological advances on the Gnih system in fish are scarce, contradictory, and inconclusive. Research on the fish Gnih system appears necessary to better clarify its role in the neuroendocrine and environmental control of vertebrate reproduction. In this study, we cloned a full\u2010length sequence for the Gnih precursor of a flatfish, the Senegalese sole, coding for three putative Gnih peptides (ssGnih). We also generated specific antibodies against these ssGnih peptides, and used them to localize Gnih cells and their projections in the brain and pituitary. The expression of <jats:italic>gnih<\/jats:italic> was particularly evident in the diencephalon, but also in the olfactory bulbs\/cerebral hemispheres, optic tectum\/tegmentum, retina, and pituitary. The three antibodies used provided consistent results and showed that ssGnih\u2010immunoreactive perikarya were present in the olfactory bulbs, ventral telencephalon, caudal preoptic area, dorsal tegmentum and rostral rhombencephalon, and their fibers innervated the brain and pituitary profusely. Intramuscular injection of ssGnih\u20103 provoked a significant reduction in <jats:italic>gnrh\u20103<\/jats:italic> and <jats:italic>lh<\/jats:italic> expression, whereas ssGnih\u20102 treatment did not affect transcript levels of the main reproductive genes. Our results reveal the existence of a functional Gnih system in the sole brain, profusely innervating different brain areas and the pituitary gland, which could represent an important factor in the neuroendocrine control of flatfish reproduction.<\/jats:p>","DOI":"10.1002\/cne.24339","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T02:58:42Z","timestamp":1508209122000},"page":"349-370","source":"Crossref","is-referenced-by-count":37,"title":["Gonadotropin\u2010inhibitory hormone in the flatfish, <i>Solea senegalensis<\/i>: Molecular cloning, brain localization and physiological effects"],"prefix":"10.1002","volume":"526","author":[{"given":"Mar\u00eda","family":"Aliaga\u2010Guerrero","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Marine and Environmental Sciences University of C\u00e1diz, Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3) Puerto Real Spain"},{"name":"INMAR\u2010CACYTMAR Research Institutes, Puerto Real University Campus Puerto Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Paullada\u2010Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Marine and Environmental Sciences University of C\u00e1diz, Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3) Puerto Real Spain"},{"name":"INMAR\u2010CACYTMAR Research Institutes, Puerto Real University Campus Puerto Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Piquer","sequence":"additional","affiliation":[{"name":"Institute of Aquaculture of Torre la Sal, CSIC Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evaristo L.","family":"Ma\u00f1an\u00f3s","sequence":"additional","affiliation":[{"name":"Institute of Aquaculture of Torre la Sal, CSIC Castell\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-5506","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Mu\u00f1oz\u2010Cueto","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Marine and Environmental Sciences University of C\u00e1diz, Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3) Puerto Real Spain"},{"name":"INMAR\u2010CACYTMAR Research Institutes, Puerto Real University Campus Puerto Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06494"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01062.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2047"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2014.06.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2010.05.034"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730411435303"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2006.04.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-012-0312-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10253"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.05.073"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2016.06.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-10-0494"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01260.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0575"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2011.08.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2017.02.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01784.x"},{"issue":"5","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12377","article-title":"Gonadotropin\u2010inhibitory hormone in the cichlid fish Cichlasoma dimerus: Structure, brain distribution and differential effects on the secretion of gonadotropins and growth hormone","volume":"28","author":"Yorio M. 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