{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:20:55Z","timestamp":1790637655869,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T00:00:00Z","timestamp":1513468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K070025"],"award-info":[{"award-number":["16K070025"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The spinocerebellar projection has an essential role in sensorimotor coordination of limbs and the trunk. Multiple groups of spinocerebellar projections have been identified in retrograde labeling studies. In this study, we aimed at characterizing projection patterns of these groups using a combination of anterograde labeling of the thoracic spinal cord and aldolase C immunostaining of longitudinal stripes of the cerebellar cortex in the mouse. We reconstructed 22 single spinocerebellar axons, wholly in the cerebellum and brain stem and partly, in the spinal cord. They were classified into three groups, (a) non\u2010crossed axons of Clarke's column neurons (NCC, 8 axons), (b) non\u2010crossed axons of marginal Clarke's column neurons (NMCC, 7 axons), and (c) crossed axons of neurons in the medial ventral horn (CMVH, 7 axons), based on previous retrograde labeling studies. While NCC axons projected mainly to multiple bilateral stripes in vermal lobules II\u2013IV and VIII\u2013IX, and the ipsilateral medial cerebellar nucleus, NMCC axons projected mainly to ipsilateral stripes in paravermal lobules II\u2013V and copula pyramidis, and the anterior interposed nucleus. CMVH axons projected bilaterally to multiple stripes in lobules II\u2013V with a small number of terminals but had abundant collaterals in the spinal cord and medullary reticular nuclei as well as in the vestibular and cerebellar nuclei. The results indicate that, while CMVH axons overlap with propriospinal and spinoreticular projections, NCC and NMCC axons are primarily spinocerebellar axons, which seem to be involved in relatively more proximal and distal sensorimotor controls, respectively.<\/jats:p>","DOI":"10.1002\/cne.24360","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:44:21Z","timestamp":1511239461000},"page":"681-706","source":"Crossref","is-referenced-by-count":30,"title":["Single axonal morphology and termination to cerebellar aldolase C stripes characterize distinct spinocerebellar projection systems originating from the thoracic spinal cord in the mouse"],"prefix":"10.1002","volume":"526","author":[{"given":"Yuanjun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Systems Neurophysiology Graduate School, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika Pooja","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Systems Neurophysiology Graduate School, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"},{"name":"Imperial College London Medicine MBBS\/BSc, South Kensington Campus London SW7 2AZ United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon Anokye","family":"Sarpong","sequence":"additional","affiliation":[{"name":"Department of Systems Neurophysiology Graduate School, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Sasamura","sequence":"additional","affiliation":[{"name":"Department of Systems Neurophysiology Graduate School, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-9882","authenticated-orcid":false,"given":"Izumi","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Systems Neurophysiology Graduate School, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"},{"name":"Center for Brain Integration Research, Tokyo Medical and Dental University, 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108519 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902910405"},{"key":"e_1_2_8_3_1","volume-title":"Neurological anatomy: In relation to clinical medicine","author":"Brodal A.","year":"1981"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"438","article-title":"The vestibular nuclei in the cat","volume":"91","author":"Brodal A.","year":"1957","journal-title":"Journal of Anatomy"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981214)402:2<264::AID-CNE10>3.0.CO;2-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000270"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0861-13.2013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086679"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-011-0339-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2637"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90414-6"},{"issue":"2","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cne.902550209","article-title":"Somatosensory nuclei in the brainstem of the rat: Independent projections to the thalamus and cerebellum","volume":"255","author":"John L. 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