{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:35:35Z","timestamp":1790264135330,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY012736"],"award-info":[{"award-number":["R01 EY012736"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 EY013933"],"award-info":[{"award-number":["T32 EY013933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30 EY019007"],"award-info":[{"award-number":["5P30 EY019007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA013696"],"award-info":[{"award-number":["P30 CA013696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prior to forming and refining synaptic connections, axons of projection neurons navigate long distances to their targets. While much is known about guidance cues for axon navigation through intermediate choice points, whether and how axons are organized within tracts is less clear. Here we analyze the organization of retinal ganglion cell (RGC) axons in the developing mouse retinogeniculate pathway. RGC axons are organized by both eye\u2010specificity and topography in the optic nerve and tract: ipsilateral RGC axons are segregated from contralateral axons and are offset laterally in the tract relative to contralateral axon topographic position. To identify potential cell\u2010autonomous factors contributing to the segregation of ipsilateral and contralateral RGC axons in the visual pathway, we assessed their fasciculation behavior in a retinal explant assay. Ipsilateral RGC neurites self\u2010fasciculate more than contralateral neurites in vitro and maintain this difference in the presence of extrinsic chiasm cues. To further probe the role of axon self\u2010association in circuit formation in vivo, we examined RGC axon organization and fasciculation in an EphB1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mutant, in which a subset of ipsilateral RGC axons aberrantly crosses the midline but targets the ipsilateral zone in the dorsal lateral geniculate nucleus on the opposite side. Aberrantly crossing axons retain their association with ipsilateral axons in the contralateral tract, indicating that cohort\u2010specific axon affinity is maintained independently of guidance signals present at the midline. Our results provide a comprehensive assessment of RGC axon organization in the retinogeniculate pathway and suggest that axon self\u2010association contributes to pre\u2010target axon organization.\n                  <\/jats:p>","DOI":"10.1002\/cne.24392","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T03:34:12Z","timestamp":1515641652000},"page":"1077-1096","source":"Crossref","is-referenced-by-count":31,"title":["Eye\u2010specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway"],"prefix":"10.1002","volume":"526","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7601-6143","authenticated-orcid":false,"given":"Austen A.","family":"Sitko","sequence":"first","affiliation":[{"name":"Department of Neuroscience, College of Physicians and Surgeons Columbia University New York New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kuwajima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons Columbia University New York New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, College of Physicians and Surgeons Columbia University New York New York 10032"},{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons Columbia University New York New York 10032"},{"name":"Department of Ophthalmology College of Physicians and Surgeons, Columbia University New York New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00713"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618606114"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990405)406:2<251::AID-CNE8>3.0.CO;2-E"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903440103"},{"issue":"3","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1242\/dev.108.3.515","article-title":"The early development of retinal ganglion cells with uncrossed axons in the mouse: Retinal position and axonal course","volume":"108","author":"Colello R. 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