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Laser shots at the border of the optic disc produced massive retinal lesions, while low power laser shots in the retina produced restricted retinal lesions. These massive and restricted retinal lesions were intended to simulate glaucoma and diabetic retinopathy, respectively. We used a Neodymium\u2010YAG dual frequency laser to make the lesions. We measured Layer III blobs in CytOx\u2010reacted tangential sections of flat\u2010mounted preparations of V1. The plasticity of the blob system and that of the ocular dominance columns (ODC) varied with the degree of retinal lesions. We found that changes in the blob system were different from that of the ODC. Blob sizes changed drastically in the region corresponding to the retinal lesion. Blobs were larger and subjectively darker above and below the non deprived ODC than in the deprived columns. With restricted lesions, blobs corresponding to the ND columns had sizes similar to those from non\u2010lesioned areas. In contrast, blobs corresponding to the deprived columns were smaller than those from nonlesioned areas. With massive lesions, ND blobs were larger than the deprived blobs. Plastic changes in blobs described here occur much earlier than previously described.<\/jats:p>","DOI":"10.1002\/cne.24434","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:11:10Z","timestamp":1521990670000},"page":"600-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Time course of cytochrome oxidase blob plasticity in the primary visual cortex of adult monkeys after retinal laser lesions"],"prefix":"10.1002","volume":"527","author":[{"given":"Mariana F.","family":"Farias","sequence":"first","affiliation":[{"name":"Laboratory of Cognitive Physiology Instituto de Biof\u00edsica Carlos Chagas Filho, UFRJ Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie G.","family":"Ungerleider","sequence":"additional","affiliation":[{"name":"Laboratory of Brain and Cognition National Institute of Mental Health, National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine UFRJ Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karla J.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Physiology Instituto de Biof\u00edsica Carlos Chagas Filho, UFRJ Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana G. 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