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However, structural properties of astrocytes residing within different brainstem regions are unknown. In this study astrocytes in the preB\u00f6tC, an intermediate reticular formation (IRF) region with respiratory\u2010related function, and a region of the nucleus tractus solitarius (NTS) in adult rats were reconstructed and their morphological features were compared. Detailed morphological analysis revealed that preB\u00f6tC astrocytes are structurally more complex than those residing within the functionally distinct neighboring IRF region, or the NTS, located at the dorsal aspect of the medulla oblongata. Structural analyses of the brainstem microvasculature indicated no significant regional differences in vascular properties. We hypothesize that high morphological complexity of preB\u00f6tC astrocytes reflects their functional role in providing structural\/metabolic support and modulation of the key neuronal circuits essential for breathing, as well as constraints imposed by arrangements of associated neurons and\/or other local structural features of the brainstem parenchyma.<\/jats:p>","DOI":"10.1002\/cne.24472","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T05:28:25Z","timestamp":1528694905000},"page":"2032-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Morphometric analysis of astrocytes in brainstem respiratory regions"],"prefix":"10.1002","volume":"526","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-9979","authenticated-orcid":false,"given":"Shahriar","family":"SheikhBahaei","sequence":"first","affiliation":[{"name":"Cellular and Systems Neurobiology Section National 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