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To overcome this, we used a projection\u2010based targeting strategy to selectively label CLA principal neurons. Combined with adeno\u2010associated virus (AAV) and monosynaptic rabies tracing techniques, we systematically examined the pre\u2010synaptic input and axonal output of this structure. We found that CLA neurons projecting to retrosplenial cortex (RSP) collateralize extensively to innervate a variety of higher\u2010order cortical regions. No subcortical labeling was found, with the exception of sparse terminals in the basolateral amygdala (BLA). This pattern of output was similar to cingulate\u2010 and visual cortex\u2010projecting CLA neurons, suggesting a common targeting scheme among these projection\u2010defined populations. Rabies virus tracing directly demonstrated widespread synaptic inputs to RSP\u2010projecting CLA neurons from both cortical and subcortical areas. The strongest inputs arose from classically defined limbic regions, including medial prefrontal cortex, anterior cingulate, BLA, ventral hippocampus, and neuromodulatory systems such as the dorsal raphe and cholinergic basal forebrain. These results suggest that the CLA may integrate information related to the emotional salience of stimuli and may globally modulate cortical state by broadcasting its output uniformly across a variety of higher cognitive centers.<\/jats:p>","DOI":"10.1002\/cne.24502","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T11:53:47Z","timestamp":1537876427000},"page":"2428-2443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Input\u2013output organization of the mouse claustrum"],"prefix":"10.1002","volume":"526","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-8863","authenticated-orcid":false,"given":"Brian","family":"Zingg","sequence":"first","affiliation":[{"name":"Zilkha Neurogenetic Institute University of Southern California  Los Angeles California"},{"name":"Department of Physiology and Neuroscience Keck School of Medicine, University of Southern California  Los Angeles California"},{"name":"Neuroscience Graduate Program University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Zilkha Neurogenetic Institute University of Southern California  Los Angeles California"},{"name":"Department of Neurology Keck School of Medicine, University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhong Whit","family":"Tao","sequence":"additional","affiliation":[{"name":"Zilkha Neurogenetic Institute University of Southern California  Los Angeles California"},{"name":"Department of Physiology and Neuroscience Keck School of Medicine, University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li I.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zilkha Neurogenetic Institute University of Southern California  Los Angeles California"},{"name":"Department of Physiology and Neuroscience Keck School of Medicine, University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"633","article-title":"Mapping synaptic cortico\u2010claustral connectivity in the mouse","volume":"520","author":"Atlan G.","year":"2016","journal-title":"Journal of Comparative Neurology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.097"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1289-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1837-17.2017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4553"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90152-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1661"},{"issue":"140216","key":"e_1_2_6_9_1","first-page":"1","article-title":"An investigation of the false discovery rate and the misinterpretation of P values","volume":"1","author":"Colquhoun D.","year":"2014","journal-title":"Royal Society Open Science"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903160205"},{"key":"e_1_2_6_11_1","volume-title":"The Allen reference atlas: A digital color brain atlas of the C57BL\/6J male mouse","author":"Dong H. 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