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Characteristic features of this disease include a decrease in specific subpopulations of GABAergic cells and deterioration of social interaction. The purpose of this study is to assess if a deep and short\u2010hypothermic treatment can ameliorate this damage in a model of PA. Rats offsprings were exposed to 19\u2009min of asphyxia by immersing the uterus horns in water at 37\u2009\u00b0C followed by 30\u2009min in air at 10\u2009\u00b0C that resulted in 15\u2009\u00b0C body temperature. At postnatal day 36\u201338, the rats were tested in the open field and social interaction paradigms and processed for immunostaining of calbindin and reelin. A brief exposure to deep hypothermia reversed the deterioration produced by PA in play soliciting. PA decreased the density of calbindin neurons in layer II of the Anterior Insular Cortex, while deep hypothermia reversed this effect. Paradoxically, in AIC, there was a significant increase in the number of reelin\u2010secreting neurons in layers II and III generated by PA and this increase was reversed by hypothermia. This suggests a compensatory mechanism, where reelin neurons trend to compensate for the loss of calbindin neurons, at least within Anterior Insular Cortex. Finally, the deep hypothermic shock might represent a valuable therapeutic alternative to treat PA.<\/jats:p>","DOI":"10.1002\/cne.24539","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T10:39:46Z","timestamp":1537958386000},"page":"362-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deep hypothermia reverses behavioral and histological alterations in a rat model of perinatal asphyxia"],"prefix":"10.1002","volume":"527","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-5707","authenticated-orcid":false,"given":"Pablo","family":"V\u00e1zquez\u2010Borsetti","sequence":"first","affiliation":[{"name":"Laboratorio de Neuropatolog\u00eda Experimental Instituto de Biolog\u00eda Celular y Neurociencia \u201cProf. E. 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