{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:05:31Z","timestamp":1772118331590,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000582","name":"Carnegie Trust for the Universities of Scotland","doi-asserted-by":"publisher","award":["50341"],"award-info":[{"award-number":["50341"]}],"id":[{"id":"10.13039\/501100000582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/R004854\/1"],"award-info":[{"award-number":["EP\/R004854\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/P030017\/1"],"award-info":[{"award-number":["EP\/P030017\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RG160373"],"award-info":[{"award-number":["RG160373"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dyslexia is a common neurodevelopmental disorder caused by a significant genetic component. The\n                    <jats:italic>KIAA0319<\/jats:italic>\n                    gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood. Initial RNA\u2010interference studies in rats suggested a role in neuronal migration whereas subsequent work with double knock\u2010out mouse models for both\n                    <jats:italic>Kiaa0319<\/jats:italic>\n                    and its paralogue\n                    <jats:italic>Kiaa0319\u2010like<\/jats:italic>\n                    reported effects in the auditory system but not in neuronal migration. To further understand the role of\n                    <jats:italic>KIAA0319<\/jats:italic>\n                    during neurodevelopment, we carried out an expression study of its zebrafish orthologue at different embryonic stages. We used different approaches including RNAscope in situ hybridization combined with light\u2010sheet microscopy. The results show particularly high expression during the first few hours of development. Later, expression becomes localized in well\u2010defined structures. In addition to high expression in the brain, we report for the first time expression in the eyes and the notochord. Surprisingly,\n                    <jats:italic>kiaa0319\u2010like,<\/jats:italic>\n                    which generally shows a similar expression pattern to\n                    <jats:italic>kiaa0319<\/jats:italic>\n                    , was not expressed in the notochord suggesting a distinct role for\n                    <jats:italic>kiaa0319<\/jats:italic>\n                    in this structure. This observation was supported by the identification of notochord enhancers enriched upstream of the\n                    <jats:italic>KIAA0319<\/jats:italic>\n                    transcription start site, in both zebrafish and humans. This study supports a developmental role for\n                    <jats:italic>KIAA0319<\/jats:italic>\n                    in the brain as well as in other developing structures, particularly in the notochord which, is key for establishing body patterning in vertebrates.\n                  <\/jats:p>","DOI":"10.1002\/cne.24696","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T11:49:23Z","timestamp":1554464963000},"page":"2634-2643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The dyslexia susceptibility\n                    <i>KIAA0319<\/i>\n                    gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration"],"prefix":"10.1002","volume":"527","author":[{"given":"Monika","family":"Gostic","sequence":"first","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"},{"name":"Biomedical Sciences Research Complex University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Martinelli","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"},{"name":"Biomedical Sciences Research Complex University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Tucker","sequence":"additional","affiliation":[{"name":"College of Medicine and Veterinary Medicine The University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyi","family":"Yang","sequence":"additional","affiliation":[{"name":"SUPA, School of Physics and Astronomy University of St Andrews  St Andrews UK"},{"name":"School of Psychology and Neuroscience University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Gasparoli","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade\u2010Yi","family":"Ewart","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"},{"name":"School of Psychology and Neuroscience University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishan","family":"Dholakia","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Research Complex University of St Andrews  St Andrews UK"},{"name":"SUPA, School of Physics and Astronomy University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith T.","family":"Sillar","sequence":"additional","affiliation":[{"name":"School of Psychology and Neuroscience University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Tello","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"},{"name":"Biomedical Sciences Research Complex University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-8602","authenticated-orcid":false,"given":"Silvia","family":"Paracchini","sequence":"additional","affiliation":[{"name":"School of Medicine University of St Andrews  St Andrews UK"},{"name":"Biomedical Sciences Research Complex University of St Andrews  St Andrews UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065179"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.10.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dys.1464"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098439"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063123"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1456"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01677060802354328"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000436"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90627-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605085113"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1772"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3836"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr064"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0055-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx269"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14149"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1010172"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280602"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035618"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.229102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-169x.2002.00624.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1282-1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020580"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2003.10.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.081034"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5020285"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-011-9091-6"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.adgen.2016.08.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092312"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl089"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp154"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.06.056"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643294.2012.677420"},{"key":"e_1_2_8_38_1","volume-title":"RStudio: Integrated development for R","author":"RStudioTeam","year":"2015"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9214"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.002"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.043"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MICS.0000006847.09037.3a"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/dys.186"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01812"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348431"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.01.009"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.10.002"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2707"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.514"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12170"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-007-9051-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm358"},{"issue":"1","key":"e_1_2_8_53_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/dev.122.1.271","article-title":"Developmental regulation of zebrafish MyoD in wild\u2010type, no tail and spadetail embryos","volume":"122","author":"Weinberg E. S.","year":"1996","journal-title":"Development (Cambridge, England)"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.24696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cne.24696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T13:55:24Z","timestamp":1694267724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.24696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":52,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/cne.24696"],"URL":"https:\/\/doi.org\/10.1002\/cne.24696","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/267617","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"assertion":[{"value":"2018-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}