{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:37Z","timestamp":1791300517982,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P01NS08351"],"award-info":[{"award-number":["P01NS08351"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human early postnatal brain contains late migratory streams of immature interneurons that are directed to cortex and other focal brain regions. However, such migration is not observed in rodent brain, and whether other small animal models capture this aspect of human brain development is unclear. Here, we investigated whether the gyrencephalic ferret cortex possesses human\u2010equivalent postnatal streams of doublecortin positive (DCX+) young neurons. We mapped DCX+ cells in the brains of ferrets at P20 (analogous to human term gestation), P40, P65, and P90. In addition to the rostral migratory stream, we identified three populations of young neurons with migratory morphology at P20 oriented toward: (a) prefrontal cortex, (b) dorsal posterior sigmoid gyrus, and (c) occipital lobe. These three neuronal collections were all present at P20 and became extinguished by P90 (equivalent to human postnatal age 2 years). DCX+ cells in such collections all expressed GAD67, identifying them as interneurons, and they variously expressed the subtype markers SP8 and secretagogin (SCGN). SCGN+ interneurons appeared in thick sections to be oriented from white matter toward multiple cortical regions, and persistent SCGN\u2010expressing cells were observed in cortex. These findings indicate that ferret is a suitable animal model to study the human\u2010relevant process of late postnatal cortical interneuron integration into multiple regions of cortex.<\/jats:p>","DOI":"10.1002\/cne.24711","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T16:39:31Z","timestamp":1556901571000},"page":"2843-2859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams"],"prefix":"10.1002","volume":"527","author":[{"given":"Justin K.","family":"Ellis","sequence":"first","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California, San Francisco  San Francisco California"},{"name":"Department of Pediatrics and Neurological Surgery University of California, San Francisco  San Francisco 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University of California, San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mcquillen","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California, San Francisco  San Francisco California"},{"name":"Department of Pediatrics and Neurological Surgery University of California, San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-0060","authenticated-orcid":false,"given":"David H.","family":"Rowitch","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California, San Francisco  San Francisco California"},{"name":"Department of Pediatrics and Neurological Surgery University of California, San Francisco  San Francisco California"},{"name":"Department of 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