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CGE\u2010derived cortical interneurons, which comprise around 30% of all cortical interneurons, mainly express Htr3a, calretinin (CR), Reelin (RELN) and vasoactive intestinal polypeptide (VIP). In the present study, we show that transcription factors <jats:italic>Sp8<\/jats:italic> and <jats:italic>Sp9<\/jats:italic> are co\u2010expressed in the subventricular zone (SVZ) of the dorsal CGE. Conditional knockout of <jats:italic>Sp8\/9<\/jats:italic> using the <jats:italic>Gsx2\u2010Cre<\/jats:italic> transgenic line results in severe loss of CGE\u2010derived cortical interneurons. We observed migration defects of <jats:italic>Sp8\/9<\/jats:italic> double mutant CGE\u2010derived cortical interneurons as they had longer leading processes than controls and they ectopically accumulated in the CGE. <jats:italic>Dlx5\/6\u2010CIE<\/jats:italic> conditional deletion of <jats:italic>Sp8\/9<\/jats:italic> also leads to a significant reduction in the CGE\u2010derived cortical interneurons. We provide evidence that <jats:italic>Sp8<\/jats:italic>\/<jats:italic>9<\/jats:italic> coordinately regulate CGE\u2010derived cortical interneuron development in part through repressing the expression of <jats:italic>Pak3<\/jats:italic>, <jats:italic>Robo1<\/jats:italic>, and <jats:italic>Slit1<\/jats:italic>. Finally, we show that <jats:italic>Cxcl14<\/jats:italic>, a member of the CXC chemokine family, is mainly expressed in CGE\u2010derived interneurons in cortical layers I and II, and its expression is critically dependent on SP8.<\/jats:p>","DOI":"10.1002\/cne.24712","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T17:39:12Z","timestamp":1557423552000},"page":"2860-2874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Transcription factors <i>Sp8<\/i> and <i>Sp9<\/i> regulate the development of caudal ganglionic eminence\u2010derived cortical interneurons"],"prefix":"10.1002","volume":"527","author":[{"given":"Song","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Department of Neurology, Zhongshan Hospital Fudan University  Shanghai 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University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Department of Neurology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Department of Neurology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Department of Neurology, Zhongshan Hospital 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