{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:07Z","timestamp":1790650207545,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:00:00Z","timestamp":1559433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81674002"],"award-info":[{"award-number":["81674002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of peripheral nerve injury has attracted increased attention. Allografting has been proposed as a potential treatment strategy for peripheral nerve injury. Moreover, cryopreservation may provide almost unlimited graft material. We investigated whether cold\u2010inducible RNA\u2010binding protein (CIRP) could protect peripheral nerves during cryopreservation to promote regeneration postoperation. First, CIRP was highly expressed after pretreatment at 32\u00b0C. After 4\u2009weeks of cryopreservation, the increased live cells, low Bax\/Bcl\u20102 ratio and high nerve growth factor and glial cell\u2010derived neurotrophic factor levels in the 32\u00b0C group demonstrated high nerve graft viability. At 4\u2009weeks postoperation, 32\u00b0C\u2010Allo group demonstrated low plasma levels of interleukin\u20106 and interferon\u2010gamma and a diminished cellular immune response. At 20\u2009weeks postoperation, nerve regeneration in the 32\u00b0C\u2010Allo group was similar to that in the fresh isograft group and superior to that in the 4\u00b0C\u2010Allo and 15\u00b0C\u2010Allo groups. Moreover, the compound muscle action potential and the motor nerve conduction velocity of the 32\u00b0C\u2010Allo group were equal to those of the fresh isograft group. In conclusion, CIRP induction increased Schwann cell biological activity, inhibited cell apoptosis, reduced immune rejection, and promoted recipient nerve regeneration. Thus, CIRP could exert protective effects during nerve storage and stimulate regeneration in peripheral nerve reconstruction.<\/jats:p>","DOI":"10.1002\/cne.24716","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:38:44Z","timestamp":1558532324000},"page":"2885-2895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nerve regeneration in rat peripheral nerve allografts: Evaluation of cold\u2010inducible RNA\u2010binding protein in nerve storage and regeneration"],"prefix":"10.1002","volume":"527","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-1045","authenticated-orcid":false,"given":"Zijian","family":"Li","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"},{"name":"Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"},{"name":"Nanchong Hospital of Traditional Chinese Medicine  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingru","family":"Huang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65039-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1227::AID-MUS11>3.0.CO;2-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.5.0924"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.064"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.11.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1996)17:6<301::AID-MICR3>3.0.CO;2-K"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2451"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.19.2279"},{"issue":"350","key":"e_1_2_8_10_1","first-page":"307268","article-title":"Cryopreservation of embryos and oocytes in human assisted reproduction","volume":"2014","author":"Konc J.","year":"2014","journal-title":"BioMed Research International"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6843"},{"issue":"1","key":"e_1_2_8_12_1","first-page":"43","article-title":"A new generation of proto\u2010oncogenes: Cold\u2010inducible RNA binding proteins","volume":"1805","author":"Leonart M. 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