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The UPR is initiated when the processing capacity of the endoplasmic reticulum (ER) is overwhelmed. Misfolded proteins accumulate and can activate ER stress sensors; PKR\u2010like endoplasmic reticulum kinase (PERK), inositol\u2010requiring enzyme 1 (IRE1), activated transcription factor 6 (ATF6) and their downstream targets glucose\u2010regulated protein 78 (GRP78), glucose\u2010regulated protein 94 (GRP94) and protein disulfide isomerase (PDI). In order to provide a fuller appreciation of the possible importance of ER stress\u2010associated proteins in the context of cerebellar disease, we have profiled the expression of ER stress sensors and their downstream targets in the developing cerebellar cortex in postnatal rat. Activation of PERK and IRE1 stress sensors was observed for the first time in normally developing granule cell precursors. A second proliferative pPERK\u2010positive population was also detected in the internal granular layer (IGL). In general, the density of UPR protein\u2010positive cells was found to decrease significantly when profiles in early and late postnatal ages were compared. These data may be relevant to studies of medulloblastoma and warrant further investigation.<\/jats:p>","DOI":"10.1002\/cne.24718","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T15:24:06Z","timestamp":1558970646000},"page":"2910-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Profile of the unfolded protein response in rat cerebellar cortical development"],"prefix":"10.1002","volume":"527","author":[{"given":"Michelle","family":"Naughton","sequence":"first","affiliation":[{"name":"Galway Neuroscience Centre, School of Natural Sciences National University of Ireland  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"McMahon","sequence":"additional","affiliation":[{"name":"Galway Neuroscience Centre, School of Natural Sciences National University of Ireland  Galway 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