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Two neural pathways responsible for odor\u2010evoked locomotion have been characterized in the sea lamprey (<jats:italic>Petromyzon marinus<\/jats:italic> L.), a basal vertebrate. There is a medial pathway originating in the medial olfactory bulb (OB) and a lateral pathway originating from the rest of the OB. These olfactomotor pathways are present throughout the life cycle of lampreys, but olfactory\u2010driven behaviors differ according to the developmental stage. Among possible mechanisms, dopaminergic (DA) modulation in the OB might explain the behavioral changes. Here, we examined DA modulation of olfactory transmission in lampreys. Immunofluorescence against DA revealed immunoreactivity in the OB that was denser in the medial part (medOB), where processes were observed close to primary olfactory afferents and projection neurons. Dopaminergic neurons labeled by tracer injections in the medOB were located in the OB, the posterior tuberculum, and the dorsal hypothalamic nucleus, suggesting the presence of both intrinsic and extrinsic DA innervation. Electrical stimulation of the olfactory nerve in an in vitro whole\u2010brain preparation elicited synaptic responses in reticulospinal cells that were modulated by DA. Local injection of DA agonists in the medOB decreased the reticulospinal cell responses whereas the D2 receptor antagonist raclopride increased the response amplitude. These observations suggest that DA in the medOB could modulate odor\u2010evoked locomotion. Altogether, these results show the presence of a DA innervation within the medOB that may play a role in modulating olfactory inputs to the motor command system of lampreys.<\/jats:p>","DOI":"10.1002\/cne.24743","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T06:19:08Z","timestamp":1562653148000},"page":"118-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dopaminergic modulation of olfactory\u2010evoked motor output in sea lampreys (<i>Petromyzon marinus<\/i> L.)"],"prefix":"10.1002","volume":"528","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-7660","authenticated-orcid":false,"given":"Philippe\u2010Antoine","family":"Beaus\u00e9jour","sequence":"first","affiliation":[{"name":"D\u00e9partement de neurosciences Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec 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