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We investigated the mRNA expression and immunohistochemical localization of vesicular nucleotide transporter (VNUT) in the rat carotid body. RT\u2010PCR detected mRNA expression of VNUT in extracts of the tissue. Immunoreactivity for VNUT was localized in a part of type I cells immunoreactive for synaptophysin (SYN), but not in glial\u2010like type II cells immunoreactive for S100 and S100B. Among SYN\u2010immunoreactive type I cells, VNUT immunoreactivity was selectively localized in the sub\u2010population of tyrosine hydroxylase (TH)\u2010immunorective type I cells associated with nerve endings immunoreactive for the P2X3 purinoceptor; however, it was not detected in the sub\u2010population of type I cells immunoreactive for dopamine beta\u2010hydroxylase. Multi\u2010immunolabeling for VNUT, P2X3, and Bassoon revealed that Bassoon\u2010immunoreactive products were localized in type I cells with VNUT immunoreactivity, and accumulated on the contact side of P2X3\u2010immunoreactive nerve endings. These results revealed the selective localization of VNUT in the subpopulation of TH\u2010immunoreactive type I cells attached to sensory nerve endings and suggested that these cells release ATP by exocytosis for chemosensory transmission in the carotid body.<\/jats:p>","DOI":"10.1002\/cne.24837","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T11:57:56Z","timestamp":1575633476000},"page":"1486-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vesicular nucleotide transporter\u2010immunoreactive type I cells associated with P2X3\u2010immunoreactive nerve endings in the rat carotid body"],"prefix":"10.1002","volume":"528","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-0623","authenticated-orcid":false,"given":"Takuya","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Anatomy (Cell Biology) Iwate Medical University  Yahaba 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