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Among others, promising approaches include optogenetics and prosthetic implants, which aim to bypass lost photoreceptors (PRs). Naturally, the efficacy of these therapeutic strategies will depend on inner retinal structural and functional preservation. The present study shows that in photoinducible I307N rhodopsin mice (Translational Vision Research Model 4 [Tvrm4]), a 12k lux light exposure eliminates PRs in the central retina in 1 week, but interneurons and their synapses are maintained for as long as 9\u2009weeks postinduction. Despite bipolar cell dendritic retraction and moderate loss of horizontal cells, the survival rate of various cell types is very high. Significant preservation of conventional synapses and gap junctions in the inner plexiform layer is also observed. We found the number of synaptic ribbons to gradually decline and their ultrastructure to become transiently abnormal, although based on our findings intrinsic retinal architecture is maintained despite complete loss of PRs. Unlike common rodent models of PR degeneration, where the disease phenotype often interferes with retinal development, in Tvrm4 mice, the degenerative process can be induced after retinal development is complete. This time course more closely mimics the timing of disease onset in affected patients. Stability of the inner retina found in these mutants 2 months after PR degeneration suggests moderate, stereotyped remodeling in the early stages of the human disease and represents a promising finding for prompt approaches of vision restoration.<\/jats:p>","DOI":"10.1002\/cne.24838","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T07:25:54Z","timestamp":1575703554000},"page":"1502-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa"],"prefix":"10.1002","volume":"528","author":[{"given":"Antonia","family":"Stefanov","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Italian National Research Council \u2013 CNR  Pisa Italy"},{"name":"Regional Doctoral School of Neuroscience University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Novelli","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Italian National Research Council \u2013 CNR  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-599X","authenticated-orcid":false,"given":"Enrica","family":"Strettoi","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Italian National Research Council \u2013 CNR  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"issue":"10","key":"e_1_2_7_2_1","first-page":"2165","article-title":"Ultrastructural changes of photoreceptor synaptic ribbons in relation to time of day and illumination","volume":"40","author":"Adly M. 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