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However, the polysynaptic circuitry linking the brain areas involved in feeding behavior to the olfactory regions is not well known. The aim of this article was to examine such circuits. Thus, we described, using hodological tools such as transsynaptic viruses (PRV152) transported in a retrograde manner, the long\u2010distance indirect projections (two to three synapses) onto the main olfactory bulb (MOB). The \u00df\u2010subunit of the cholera toxin which is a monosynaptic retrograde tracer was used as a control to be able to differentiate between direct and indirect projections. Our tracing experiments showed that the arcuate nucleus of the hypothalamus, as a major site for regulation of food intake, sends only very indirect projections onto the MOB. Indirect projections to MOB also originate from the solitary nucleus which is involved in energy homeostasis. Other indirect projections have been evidenced in areas of the reward circuit such as VTA and accumbens nucleus. In contrast, direct projections to the MOB arise from melanin\u2010concentrating hormone and orexin neurons in the lateral hypothalamus. Functional significances of these projections are discussed in relation to the role of food odors in feeding and reward\u2010related behavior.<\/jats:p>","DOI":"10.1002\/cne.24846","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T02:24:36Z","timestamp":1577154276000},"page":"1805-1819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Centrifugal projections to the main olfactory bulb revealed by transsynaptic retrograde tracing in mice"],"prefix":"10.1002","volume":"528","author":[{"given":"Nanette Y.","family":"Schneider","sequence":"first","affiliation":[{"name":"Centre des Sciences du Go\u00fbt et de l'Alimentation (CSGA), CNRS, INRAE AgroSup Dijon, Universit\u00e9 de Bourgogne Franche\u2010Comt\u00e9  F21000, Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chaudy","sequence":"additional","affiliation":[{"name":"Centre des 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