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Differences in CB\n                    <jats:sub>1<\/jats:sub>\n                    R density between male and female rodents may be associated with distinct behavioral phenotypes. In the rat brain, CB\n                    <jats:sub>1<\/jats:sub>\n                    R expression is significantly lower in the prefrontal cortex and amygdala of estrus females than in males. However, differences in CB\n                    <jats:sub>1<\/jats:sub>\n                    R distribution due to sex over the whole mouse brain are still largely unknown. Here, we systemically investigated the expression of CB\n                    <jats:sub>1<\/jats:sub>\n                    R mRNA in the brains of both male and female adult C57BL\/6J mice using fluorescence in situ hybridization. There were significantly more CB\n                    <jats:sub>1<\/jats:sub>\n                    R positive cells in males than in females in the orbital cortex, insular cortex, cingulate cortex, piriform cortex, secondary visual cortex, caudate putamen (striatum), and ventral hippocampal CA1. There were significantly more CB\n                    <jats:sub>1<\/jats:sub>\n                    R mRNA cells in females than males in the fornix and dorsal hypothalamus. However, in some regions, strong hybridization signals without sex differences were detected, such as in the motor cortex, septum, medial habenular nucleus, and inferior colliculus. Moreover, female mice displayed different CB\n                    <jats:sub>1<\/jats:sub>\n                    R mRNA expression patterns in the medial amygdala, basolateral amygdala, and parabrachial nucleus during different phases of the estrous cycle. These findings provide a basis for understanding sexual dimorphism in physiological and pathological brain functions related to CB\n                    <jats:sub>1<\/jats:sub>\n                    R.\n                  <\/jats:p>","DOI":"10.1002\/cne.24868","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T02:55:15Z","timestamp":1580352915000},"page":"1986-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Sexual dimorphic distribution of cannabinoid 1 receptor mRNA in adult C57BL\/6J mice"],"prefix":"10.1002","volume":"528","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-3081","authenticated-orcid":false,"given":"Xue","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulin","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7547-3115","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen\u2010Hong Kong Institute of Brain Science\u2010Shenzhen Fundamental Research Institutions  Shenzhen 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