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While the SC is known to integrate input from a variety of brain regions, progress in understanding how these inputs contribute to SC\u2010dependent functions has been hindered by the paucity of data on innervation patterns to specific types of SC neurons. Here, we use G\u2010deleted rabies virus\u2010mediated monosynaptic tracing to identify inputs to excitatory and inhibitory neurons of the intermediate and deep SC. We observed stronger and more numerous projections to excitatory than inhibitory SC neurons. However, a subpopulation of excitatory neurons thought to mediate behavioral output received weaker inputs, from far fewer brain regions, than the overall population of excitatory neurons. Additionally, extrinsic inputs tended to target rostral excitatory and inhibitory SC neurons more strongly than their caudal counterparts, and commissural SC neurons tended to project to similar rostrocaudal positions in the other SC. Our findings support the view that active intrinsic processes are critical to SC\u2010dependent functions, and will enable the examination of how specific inputs contribute to these functions.<\/jats:p>","DOI":"10.1002\/cne.24888","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T02:31:55Z","timestamp":1582252315000},"page":"2254-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus"],"prefix":"10.1002","volume":"528","author":[{"given":"Ted K.","family":"Doykos","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics University of Colorado School of Medicine  Aurora Colorado"},{"name":"Neuroscience Graduate Program University of Colorado School of Medicine  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse I.","family":"Gilmer","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics University of Colorado School of Medicine  Aurora Colorado"},{"name":"Neuroscience Graduate Program University of Colorado School of Medicine  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail L.","family":"Person","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics University of Colorado School of Medicine  Aurora Colorado"},{"name":"Neuroscience Graduate Program University of Colorado School of Medicine  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-8279","authenticated-orcid":false,"given":"Gidon","family":"Felsen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics University of Colorado School of Medicine  Aurora Colorado"},{"name":"Neuroscience Graduate Program University of Colorado School of Medicine  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90155-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1945.8.2.123"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-102016-061234"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/37975"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01883.2002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901740206"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1093-17.2017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03929.1998"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00399-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07705.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0409-15.2015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.4.2000"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.061713"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00109"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90267-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90052-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3426"},{"key":"e_1_2_7_21_1","first-page":"709170","article-title":"A cortico\u2010collicular pathway for motor planning in a memory\u2010dependent perceptual decision task","author":"Duan C. 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