{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:04:43Z","timestamp":1778832283294,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BR 3479\/11\u20101"],"award-info":[{"award-number":["BR 3479\/11\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sexual characteristics of the vertebrate body change under the control of sex hormones. In mammals, genitals undergo major changes in puberty. While such bodily changes have been well documented, the associated changes in the nervous system are poorly understood. To address this issue, we studied the growth and innervation of the mouse penis throughout puberty. To this end, we measured length and thickness of the mouse penis in prepubertal (3\u20134 week old) and adult (8\u201310 week old) mice and performed fiber counts of the dorsal penile nerve. We obtained such counts with confocal imaging of proximal sections of the mouse penis after paraffin embedding and antibody staining against Protein\u2010Gene\u2010Product\u20109.5 or Neurofilament\u2010H in combination with antigen retrieval procedures. We find that the mouse penis grows roughly 1.4 times in both thickness and length. Fiber counts in the dorsal penile nerve were not different in prepubertal (1,620\u2009\u00b1\u2009165 fibers per penis) and adult (1,572\u2009\u00b1\u2009383 fibers per penis) mice, however. Antibody staining along with myelin staining by Luxol\u2010Fast\u2010Blue suggested about 57% of penile nerve fibers were myelinated. Quantification of the area of mouse somatosensory penis cortex allowed us to compare cortical magnification of the penile cortex and the whisker\u2010barrel\u2010cortex systems. This comparison suggested that 2 to 4 times less cortical area is devoted to a penile\u2010nerve\u2010fiber than to a whisker\u2010nerve\u2010fiber. The constant innervation of mouse penis through puberty suggests that the pubertal increase of cortical magnification of the penis is not simply a reflection of peripheral change.<\/jats:p>","DOI":"10.1002\/cne.24892","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T07:16:32Z","timestamp":1582528592000},"page":"2269-2279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Constant innervation despite pubertal growth of the mouse penis"],"prefix":"10.1002","volume":"528","author":[{"given":"Leopold","family":"Purkart","sequence":"first","affiliation":[{"name":"Bernstein Center for Computational Neuroscience Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Sigl\u2010Gl\u00f6ckner","sequence":"additional","affiliation":[{"name":"Bernstein Center for Computational Neuroscience Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5387-0953","authenticated-orcid":false,"given":"Michael","family":"Brecht","sequence":"additional","affiliation":[{"name":"Bernstein Center for Computational Neuroscience Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"NeuroCure Cluster of Excellence, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(77)90068-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod13.1.94"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001270406"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67512-8"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"1","article-title":"NNOS\u2010positive minor\u2010branches of the dorsal penile nerves is associated with erectile function in the bilateral cavernous injury model of rats","volume":"8","author":"Chen Y. L.","year":"2018","journal-title":"Scientific Reports"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01631399"},{"key":"e_1_2_9_8_1","volume-title":"Why is sex fun?: the evolution of human sexuality. Recorded Books","author":"Diamond J.","year":"2018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420110110"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115807"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.4.1714"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2013.17.4.469"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(73)90313-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc1950.40.321"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2013.05.010"},{"key":"e_1_2_9_16_1","first-page":"100","article-title":"A neuroanatomical correlate of sensorimotor recovery in response to repeated vaginocervical stimulation in rats","volume":"3","author":"Komisaruk B. R.","year":"2012","journal-title":"Frontiers in physiology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4067.1295"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(73)90223-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24237"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90035-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.041"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2001283"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(86)90254-2"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111410706"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020830"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431010"},{"key":"e_1_2_9_27_1","volume-title":"Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck","author":"Rea P.","year":"2016"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20010122)429:4<541::AID-CNE3>3.0.CO;2-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.036"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.08.062"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","unstructured":"Terasawa E. &Kurian J. R.(2012).Neuroendocrine mechanism of puberty. InHandbook of Neuroendocrinology(pp. 433\u2013484). Cambridge: Academic Press.https:\/\/doi.org\/10.1016\/B978-0-12-375097-6.10019-8","DOI":"10.1016\/B978-0-12-375097-6.10019-8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.223"},{"key":"e_1_2_9_33_1","volume-title":"Pheromonal regulation of puberty. Pheromones and reproduction in mammals, 95\u2013112. Chicago","author":"Vandenbergh J. G.","year":"1983"},{"key":"e_1_2_9_34_1","unstructured":"Weech D. &Ashurst J. V.(2019). Anatomy abdomen and pelvis penis dorsal nerve StatPearls. Retrieved fromhttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30247841."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-11-03355.1986"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000072061.84121.7d"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980810)397:4<561::AID-CNE8>3.0.CO;2-#"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.24892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cne.24892","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:05:36Z","timestamp":1693361136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.24892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":36,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/cne.24892"],"URL":"https:\/\/doi.org\/10.1002\/cne.24892","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,4]]},"assertion":[{"value":"2019-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}