{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:42:44Z","timestamp":1790106164240,"version":"4.0.1"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["R1478A47"],"award-info":[{"award-number":["R1478A47"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Combination of ischemia and \u03b2\u2010amyloid (A\u03b2) toxicity has been shown to simultaneously increase neuro\u2010inflammation, endogenous A\u03b2 deposition, and neurodegeneration. However, studies on the evolution of infarct and panorama of cellular degeneration as a synergistic or overlapping mechanism between ischemia and A\u03b2 toxicity are lacking. Here, we compared fluorojade B (FJB) and hematoxylin and eosin (H&amp;E) stains primarily to examine the chronology of infarct, and the viability and morphological changes in neuroglia and neurons located in different brain regions on d1, d7, and d28 post A\u03b2 toxicity and endothelin\u20101 induced ischemia (ET1) in rats. We demonstrated a regional difference in cellular degeneration between cortex, corpus callosum, striatum, globus pallidus, and thalamus after cerebral injury. Glial cells in the cortex and corpus callosum underwent delayed FJB staining from d7 to d28, but neurons in cortex disappeared within the first week of cerebral injury. Striatal lesion core and globus pallidus of A\u03b2\u2009+\u2009ET1 rats showed extensive degeneration of neuronal cells compared with ET1 rats alone starting from d1. Differential and exacerbated expressions of cyclooxygenase\u20102 might be the cause of excessive neuronal demise in the striatum of A\u03b2\u2009+\u2009ET1 rats. Such an investigation may improve our understanding to identify and manipulate a critical therapeutic window post comorbid injury.<\/jats:p>","DOI":"10.1002\/cne.24955","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T05:35:05Z","timestamp":1590298505000},"page":"421-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differential temporal and spatial post\u2010injury alterations in cerebral cell morphology and viability"],"prefix":"10.1002","volume":"529","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-1476","authenticated-orcid":false,"given":"Zareen","family":"Amtul","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology University of Western Ontario London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah N.","family":"Najdat","sequence":"additional","affiliation":[{"name":"Department of Biology University of Western Ontario London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Physiology, and Pharmacology, and Pediatrics University of Western Ontario London Canada"},{"name":"Lawson Health Research Institute London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith J.","family":"Arany","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009653126347"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903420402"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20198"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00827.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.09.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1225-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1225-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24738"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.12.013"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22985-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00735-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22706"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12149"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00047"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0904-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.096057"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07724.2001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104471"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0399-y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03980-X"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490380402"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.10.006"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.06.004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03371-6"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/MI\/2006\/30490"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10024"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000815"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.050"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6891"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)90033-7"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00214-X"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199812)30:4<433::AID-SYN10>3.0.CO;2-O"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520298009067258"},{"key":"e_1_2_11_36_1","first-page":"623","volume-title":"The American journal of pathology","author":"Garcia J. H.","year":"1993"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90428-L"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.1"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00859-2"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7628"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1563-05.2005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073634"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.03.035"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200310015"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20459"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02137-5"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00286-9"},{"issue":"3","key":"e_1_2_11_48_1","first-page":"1340","article-title":"Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest\u2010induced movement disorder","volume":"288","author":"Kanthasamy A. G.","year":"1999","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0730538.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.12.014"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401724"},{"issue":"2","key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.55782\/ane-2004-1501","article-title":"Fluoro\u2010jade and TUNEL staining as useful tools to identify ischemic brain damage following moderate extradural compression of sensorimotor cortex","volume":"64","author":"Kundrotiene J.","year":"2004","journal-title":"Acta Neurobiologiae Experimentalis"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600546"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20354"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00216.x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00063-7"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600529"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03060-8"},{"issue":"1","key":"e_1_2_11_59_1","first-page":"249","article-title":"Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons","volume":"148","author":"Morimoto T.","year":"1996","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11881-V"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20205"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-08-02746.1997"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02573.x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20181"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb03390.x"},{"key":"e_1_2_11_66_1","first-page":"456","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G.","year":"2007"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199803000-00004"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.500868"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199605000-00002"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1212"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00085-X"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/48.1.100"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01387-X"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02513-0"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7276-8_5"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws079"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.07.055"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340047031"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858405278321"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7941"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.032"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408784221306"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.094391"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.106"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/106.1.197"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.REDOX.2017.05.010"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100575"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150360547116"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00347.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.07.027"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.24955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cne.24955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.24955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:02:29Z","timestamp":1722916949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.24955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,28]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/cne.24955"],"URL":"https:\/\/doi.org\/10.1002\/cne.24955","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.24955\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.24955\/v2\/review1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,28]]},"assertion":[{"value":"2020-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}