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To examine whether the corticocuneate projections are modified during recoveries after the DCL, we injected cholera toxin subunit B into the hand representation in Cu to label the cortical neurons after various recovery times, and related results to the recovery of neural responses in the affected area 3b hand cortex. In normal New World monkeys, labeled neurons were predominately distributed in the hand regions of contralateral areas 3b, 3a, 1 and 2, parietal ventral (PV), secondary somatosensory cortex (S2), and primary motor cortex (M1), with similar distributions in the ipsilateral cortex in significantly smaller numbers. In monkeys with short\u2010term recoveries, the area 3b hand neurons were unresponsive or responded weakly to touch on the hand, while the cortical labeling pattern was largely unchanged. After longer recoveries, the area 3b hand neurons remained unresponsive, or responded to touch on the hand or somatotopically abnormal parts, depending on the lesion extent. The distributions of cortical labeled neurons were much more widespread than the normal pattern in both hemispheres, especially when lesions were incomplete. The proportion of labeled neurons in the contralateral area 3b hand cortex was not correlated with the functional reactivation in the area 3b hand cortex. Overall, our findings indicated that corticocuneate inputs increase during the functional recovery, but their functional role is uncertain.<\/jats:p>","DOI":"10.1002\/cne.25050","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T04:15:48Z","timestamp":1602130548000},"page":"1669-1702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Corticocuneate projections are altered after spinal cord dorsal column lesions in New World monkeys"],"prefix":"10.1002","volume":"529","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-897X","authenticated-orcid":false,"given":"Chia\u2010Chi","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Psychology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Psychology Vanderbilt 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