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However, the sex\u2010specific role of dopamine D1 and D2 receptors (D1R, D2R) in the deleterious effect of cocaine on adult neurogenesis has not been described yet. Here, we explored sex differences in (a) cell proliferation (5\u2032\u2010bromo\u20102\u2032\u2010deoxyuridine [BrdU]), (b) neural precursor (nestin), (c) neuronal phenotype (BrdU\/\u03b23\u2010tubulin), and (d) neuronal maturity (NeuN) in the subventricular zone (SVZ) of the lateral ventricles and striatum of mice with genetic deletion (D1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    , D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) or pharmacological blockage (SCH23390: 0.1 mg\/kg\/day\/5\u2009days; Raclopride: 0.3 mg\/kg\/day\/5\u2009days) of D1R and D2R, and treated (10 mg\/kg\/day\/5\u2009days) and then challenged (5 mg\/kg, 48\u2009hr later) with cocaine. Results indicated that hyperactivity responses to cocaine were absent in D1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and reduced in SCH23390\u2010treated mice. Activity responses to cocaine were reduced in D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    males, but absent in D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    females and increased in Raclopride\u2010treated females. D1R deletion blocked the deleterious effect of cocaine on SVZ cell proliferation in males. Cocaine\u2010exposed D1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    males also had reduced neuronal phenotype of SVZ newborn cells and increased striatal neuronal maturity. D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had lower proliferative and neural precursor responses. Cocaine in D2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    females or coadministered with Raclopride in wild\u2010type females improved SVZ cell proliferation, an effect that positively correlated with plasma brain\u2010derived neurotrophic factor (BDNF) concentrations. In conclusion, the sex\u2010specific D1R and D2R signaling on SVZ cell proliferation, neural progenitor and neuronal maturity is differentially perturbed by cocaine, and BDNF may be required to link D2R to neuroplasticity in cocaine addiction in females.\n                  <\/jats:p>","DOI":"10.1002\/cne.25052","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T23:17:01Z","timestamp":1602544621000},"page":"1724-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010specific behavioral and neurogenic responses to cocaine in mice lacking and blocking dopamine\n                    <scp>D1<\/scp>\n                    or dopamine\n                    <scp>D2<\/scp>\n                    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