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This framework of connections between visual areas is based on the laminar patterns of direct feedforward and feedback cortico\u2010cortical projections. However, this view ignores the cortico\u2010thalamo\u2010cortical projections to the pulvinar nucleus in the thalamus, which provides an alternative transthalamic information transfer between cortical areas. It was proposed that corticothalamic (CT) pathways follow a similar hierarchical pattern as cortico\u2010cortical connections. Two main types of CT projections have been recognized: drivers and modulators. Drivers originate mainly in Layer 5 whereas modulators are from Layer 6. Little is known about the laminar distribution of these projections to the pulvinar across visual cortical areas. Here, we analyzed the distribution of CT neurons projecting to the lateral posterior (LP) thalamus in two species: cats and mice. Injections of the retrograde tracer fragment B of cholera toxin (CTb) were performed in the LP. The morphology and cortical laminar distribution of CTb\u2010labeled neurons was assessed. In cats, neurons were mostly found in Layer 6 except in Area 17, where they were mostly in Layer 5. In contrast, CT neurons in mice were mostly located in Layer 6 across all areas. Thus, our results demonstrate that CT projections in mice do not follow the same organization as cats suggesting that the transthalamic pathways play distinct roles in these species.<\/jats:p>","DOI":"10.1002\/cne.25072","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T20:15:07Z","timestamp":1606162507000},"page":"2055-2069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laminar distribution of cortical projection neurons to the pulvinar: A comparative study in cats and mice"],"prefix":"10.1002","volume":"529","author":[{"given":"Bruno Oliveira Ferreira","family":"de Souza","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Anatomie Universit\u00e9 du Qu\u00e9bec \u00e0 Trois\u2010Rivi\u00e8res  Trois\u2010Rivi\u00e8res Qu\u00e9bec 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